FGFR2-amplified tumor clones are markedly heterogeneously distributed in carcinomas of the upper gastrointestinal tract.

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作者： Jan,Albin ^[1] ; Luca,Fahrig ^[2] ; Janna,Siemanowski ^[1] ; Jan,Rehkaemper ^[1] ; Florian,Gebauer ^[2] ; Thomas,Zander ^[3] ; Reinhard,Buettner ^[1] ; Christiane Josephine,Bruns ^[2] ; Wolfgang,Schroeder ^[2] ; Hakan,Alakus ^[2] ; Lena,Hieggelke ^[1] ; Alexander,Quaas ^[4]

作者单位： Institute of Pathology, University Hospital Cologne, Kerpener Street 62, 50937, Cologne, Germany. ^[1] Department of General, Visceral and Cancer Surgery, University Hospital Cologne, Cologne, Germany. ^[2] Department of Internal Medicine I, University Hospital Cologne, Cologne, Germany. ^[3] Institute of Pathology, University Hospital Cologne, Kerpener Street 62, 50937, Cologne, Germany. alexander.quaas@uk-koeln.de. ^[4]

关键词 Esophageal adenocarcinoma FGFR2 amplification Gastric carcinoma Morphological heterogeneity Tumor heterogeneity

主题词人类(Humans);原位杂交, 荧光(In Situ Hybridization, Fluorescence);腺癌(Adenocarcinoma);食管肿瘤(Esophageal Neoplasms);胃肿瘤(Stomach Neoplasms);基因扩增(Gene Amplification);受体, 成纤维细胞生长因子, 2型(Receptor, Fibroblast Growth Factor, Type 2)

DOI 10.1007/s00432-022-04460-w

PMID 36416959

发布时间 2023-07-19

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准确一般字义偏差语意偏离译文作用小提交