AIM2 and NLRC4-driven inflammasome activation in adult-onset Still's disease and the preliminary therapeutic effect exploration of carboxyamidotriazole.

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第一作者： Mengyuan,Duan

第一单位： Department of Pharmacology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and School of Basic Medicine, Peking Union Medical College, Beijing, 100005, China.

作者： Mengyuan,Duan ^[1] ; Min,Shen ^[2] ; Yongting,Zhou ^[1] ; Yi,He ^[1] ; Zehao,Guo ^[1] ; Caiying,Ye ^[1] ; Juan,Li ^[1] ; Lei,Zhu ^[3]

作者单位： Department of Pharmacology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and School of Basic Medicine, Peking Union Medical College, Beijing, 100005, China. ^[1] Department of Rheumatology and Clinical Immunology, Chinese Academy of Medical Sciences & Peking Union Medical College; National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID), Ministry of Science & Technology; State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital (PUMCH); Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, 100730, Beijing, China. ^[2] Department of Pharmacology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and School of Basic Medicine, Peking Union Medical College, Beijing, 100005, China. leizhu2004@126.com. ^[3]

关键词 Adult-onset Still’s disease Carboxyamidotriazole Cytokines Inflammasome