首页> Antioxidants (Basel, Switzerland)> Citronellal Attenuates Oxidative Stress-Induced Mitochondrial Damage through TRPM2/NHE1 Pathway and Effectively Inhibits Endothelial Dysfunction in Type 2 Diabetes Mellitus.

Citronellal Attenuates Oxidative Stress-Induced Mitochondrial Damage through TRPM2/NHE1 Pathway and Effectively Inhibits Endothelial Dysfunction in Type 2 Diabetes Mellitus.

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第一作者： Ya-Ling,Yin

第一单位： Sino-UK Joint Laboratory of Brain Function and Injury and Department of Physiology and Neurobiology, Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Xinxiang Medical University, Xinxiang 453003, China.;Henan International Joint Laboratory of Cardiovascular Remodeling and Drug Intervention, Xinxiang Key Laboratory of Vascular Remodeling Intervention and Molecular Targeted Therapy Drug Development, College of Pharmacy, Xinxiang Medical University, Xinxiang 453003, China.

作者： Ya-Ling,Yin ^[1] ; Huan-Huan,Wang ^[2] ; Zi-Chen,Gui ^[3] ; Shan,Mi ^[2] ; Shuang,Guo ^[4] ; Yue,Wang ^[5] ; Qian-Qian,Wang ^[2] ; Rui-Zhu,Yue ^[6] ; Lai-Biao,Lin ^[2] ; Jia-Xin,Fan ^[2] ; Xue,Zhang ^[2] ; Bing-Yan,Mao ^[2] ; Tian-Heng,Liu ^[2] ; Guang-Rui,Wan ^[2] ; He-Qin,Zhan ^[2] ; Mo-Li,Zhu ^[2] ; Lin-Hua,Jiang ^[7] ; Peng,Li ^[8]

作者单位： Sino-UK Joint Laboratory of Brain Function and Injury and Department of Physiology and Neurobiology, Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Xinxiang Medical University, Xinxiang 453003, China.;Henan International Joint Laboratory of Cardiovascular Remodeling and Drug Intervention, Xinxiang Key Laboratory of Vascular Remodeling Intervention and Molecular Targeted Therapy Drug Development, College of Pharmacy, Xinxiang Medical University, Xinxiang 453003, China. ^[1] Henan International Joint Laboratory of Cardiovascular Remodeling and Drug Intervention, Xinxiang Key Laboratory of Vascular Remodeling Intervention and Molecular Targeted Therapy Drug Development, College of Pharmacy, Xinxiang Medical University, Xinxiang 453003, China. ^[2] Hepatic Surgery Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. ^[3] Hubei Key Laboratory of Diabetes and Angiopathy, Hubei University of Science and Technology, Xianning 437100, China. ^[4] Sanquan College, Xinxiang Medical University, Xinxiang 453003, China. ^[5] Sino-UK Joint Laboratory of Brain Function and Injury and Department of Physiology and Neurobiology, Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Xinxiang Medical University, Xinxiang 453003, China. ^[6] Sino-UK Joint Laboratory of Brain Function and Injury and Department of Physiology and Neurobiology, Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Xinxiang Medical University, Xinxiang 453003, China.;School of Biomedical Sciences, Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, UK. ^[7] Sino-UK Joint Laboratory of Brain Function and Injury and Department of Physiology and Neurobiology, Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Xinxiang Medical University, Xinxiang 453003, China.;Henan International Joint Laboratory of Cardiovascular Remodeling and Drug Intervention, Xinxiang Key Laboratory of Vascular Remodeling Intervention and Molecular Targeted Therapy Drug Development, College of Pharmacy, Xinxiang Medical University, Xinxiang 453003, China.;Hubei Key Laboratory of Diabetes and Angiopathy, Hubei University of Science and Technology, Xianning 437100, China. ^[8]

关键词 NHE1 T2DM TRPM2 citronellal endothelial dysfunction

DOI 10.3390/antiox11112241

PMID 36421426

发布时间 2022-11-26

基金项目

G2022026006L/National High-End Foreign Expert Recruitment Plan of China 82271460, U1804197, 81874312/National Natural Science Foundation of China 202300410308, HNGD2022067/Research Foundation of Henan Province XYBSKYZZ505319, XYBSKYZZ201626, XYBSKYZZ202202, XYBSKYZZ201907, 2021006ZK, ZD2020006/Research Foundation of Xinxiang Medical University

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Citronellal Attenuates Oxidative Stress-Induced Mitochondrial Damage through TRPM2/NHE1 Pathway and Effectively Inhibits Endothelial Dysfunction in Type 2 Diabetes Mellitus.

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Citronellal Attenuates Oxidative Stress-Induced Mitochondrial Damage through TRPM2/NHE1 Pathway and Effectively Inhibits Endothelial Dysfunction in Type 2 Diabetes Mellitus.

Antioxidants (Basel, Switzerland)

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Antioxidants (Basel, Switzerland)

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