Results of the c-TRAK TN trial: a clinical trial utilising ctDNA mutation tracking to detect molecular residual disease and trigger intervention in patients with moderate- and high-risk early-stage triple-negative breast cancer.

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第一作者： N C,Turner

第一单位： Breast Cancer Now Research Centre, The Institute of Cancer Research, London, UK; Breast Unit, The Royal Marsden Hospital, London, UK. Electronic address: Nick.Turner@icr.ac.uk.

作者： N C,Turner ^[1] ; C,Swift ^[2] ; B,Jenkins ^[3] ; L,Kilburn ^[3] ; M,Coakley ^[2] ; M,Beaney ^[4] ; L,Fox ^[3] ; K,Goddard ^[3] ; I,Garcia-Murillas ^[4] ; P,Proszek ^[5] ; P,Hall ^[6] ; C,Harper-Wynne ^[7] ; T,Hickish ^[8] ; S,Kernaghan ^[3] ; I R,Macpherson ^[9] ; A F C,Okines ^[10] ; C,Palmieri ^[11] ; S,Perry ^[3] ; K,Randle ^[12] ; C,Snowdon ^[3] ; H,Stobart ^[12] ; A M,Wardley ^[13] ; D,Wheatley ^[14] ; S,Waters ^[15] ; M C,Winter ^[16] ; M,Hubank ^[2] ; S D,Allen ^[17] ; J M,Bliss ^[3] ; c-TRAK TN investigators

作者单位： Breast Cancer Now Research Centre, The Institute of Cancer Research, London, UK; Breast Unit, The Royal Marsden Hospital, London, UK. Electronic address: Nick.Turner@icr.ac.uk. ^[1] The Institute of Cancer Research, London, UK; The Royal Marsden NHS Foundation Trust, Sutton, Surrey, UK. ^[2] Clinical Trials and Statistics Unit, The Institute of Cancer Research, London, UK. ^[3] The Institute of Cancer Research, London, UK. ^[4] NIHR Centre for Molecular Pathology, Royal Marsden Hospital, London, UK. ^[5] University of Edinburgh, Edinburgh, UK. ^[6] Maidstone Hospital, Maidstone and Tunbridge Wells NHS Trust, Maidstone, UK. ^[7] University Hospitals Dorset NHS Foundation Trust, Bournemouth, UK. ^[8] The Beatson West of Scotland Cancer Centre, Glasgow, UK. ^[9] Breast Unit, The Royal Marsden Hospital, London, UK. ^[10] Clatterbridge Cancer Centre NHS Trust, Liverpool, Wirral, UK. ^[11] Independent Cancer Patients' Voice, London, UK. ^[12] Outreach Research & Innovation Group Ltd, Manchester, UK. ^[13] Royal Cornwall Hospitals NHS Trust, Truro, UK. ^[14] Velindre Cancer Centre, Velindre University NHS Trust, Cardiff, UK. ^[15] Sheffield Teaching Hospitals NHS Foundation Trust, Weston Park Hospital, Sheffield, UK. ^[16] The Royal Marsden NHS Foundation Trust, Sutton, Surrey, UK. ^[17]

关键词 breast cancer ctDNA molecular residual disease pembrolizumab

主题词人类(Humans);突变(Mutation);肿瘤复发, 局部(Neoplasm Recurrence, Local);前瞻性研究(Prospective Studies);肿瘤, 残余(Neoplasm, Residual)

DOI 10.1016/j.annonc.2022.11.005

PMID 36423745

发布时间 2023-02-16

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