Cage hydrocarbons as linkers in dimeric drug design: Case studies with trimethoprim and tedizolid.

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第一作者： Biljana,Vujcic

第一单位： Department of Biochemistry and Chemistry, La Trobe University, Melbourne, Victoria 3086, Australia.

作者： Biljana,Vujcic ^[1] ; Jessica,Wyllie ^[2] ; Tania ^[1] ; Jed,Burns ^[3] ; Keith F,White ^[1] ; Simon,Cromwell ^[4] ; David W,Lupton ^[4] ; Jason L,Dutton ^[1] ; Tatiana P,Soares da Costa ^[2] ; Sevan D,Houston ^[5]

作者单位： Department of Biochemistry and Chemistry, La Trobe University, Melbourne, Victoria 3086, Australia. ^[1] Department of Biochemistry and Chemistry, La Trobe University, Melbourne, Victoria 3086, Australia; School of Agriculture, Food and Wine, Waite Research Institute, The University of Adelaide, Adelaide 5063, South Australia, Australia. ^[2] School of Chemistry and Molecular Biosciences, University of Queensland, Brisbane 4072, Queensland, Australia. ^[3] School of Chemistry, Monash University, Clayton 3800, Victoria, Australia. ^[4] Department of Biochemistry and Chemistry, La Trobe University, Melbourne, Victoria 3086, Australia; Almac Sciences Ltd, 20 Seagoe Industrial Estate, Craigavon BT63 5QD, United Kingdom. Electronic address: sevan.houston@almacgroup.com. ^[5]

关键词 Cage hydrocarbons Drug dimer Tedizolid Trimethoprim

主题词甲氧苄啶(Trimethoprim);恶唑烷酮类(Oxazolidinones);抗菌药(Anti-Bacterial Agents);烃类(Hydrocarbons)

DOI 10.1016/j.bmcl.2022.129086

PMID 36423825

发布时间 2023-02-01

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