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STNM01, the RNA oligonucleotide targeting carbohydrate sulfotransferase 15, as second-line therapy for chemotherapy-refractory patients with unresectable pancreatic cancer: An open label, phase I/IIa trial.

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第一作者： Toshio,Fujisawa

第一单位： Department of Gastroenterology, Graduate School of Medicine, Juntendo University, Bunkyo-ku, Tokyo, Japan.

作者： Toshio,Fujisawa ^[1] ; Takayoshi,Tsuchiya ^[2] ; Motohiko,Kato ^[3] ; Masafumi,Mizuide ^[4] ; Kazuki,Takakura ^[5] ; Makoto,Nishimura ^[6] ; Hiromu,Kutsumi ^[7] ; Yoko,Matsuda ^[8] ; Tomio,Arai ^[9] ; Shomei,Ryozawa ^[4] ; Takao,Itoi ^[2] ; Hiroyuki,Isayama ^[1] ; Hideyuki,Saya ^[10] ; Naohisa,Yahagi ^[3]

作者单位： Department of Gastroenterology, Graduate School of Medicine, Juntendo University, Bunkyo-ku, Tokyo, Japan. ^[1] Department of Gastroenterology and Hepatology, Tokyo Medical University, Shinjuku-ku, Tokyo, Japan. ^[2] Division of Research and Development for Minimally Invasive Treatment, Cancer Center, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan. ^[3] Department of Gastroenterology, Saitama Medical University International Medical Center, Hidaka, Saitama, Japan. ^[4] Division of Gastroenterology and Hepatology, Department of Internal Medicine, Jikei University School of Medicine, Minato-ku, Tokyo, Japan. ^[5] Department of Gastroenterology, Hepatology and Nutrition, Memorial Sloan-Kettering Cancer Center, New York, NY, USA. ^[6] Center for Clinical Research and Advanced Medicine, Shiga University of Medical Science, Otsu, Shiga, Japan. ^[7] Oncology Pathology, Department of Pathology and Host-Defense, Kagawa University, Takamastu, Kagawa, Japan. ^[8] Department of Pathology, Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology, Itabashi-ku, Tokyo, Japan. ^[9] Division of Gene Regulation, Institute for Advanced Medical Research, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan. ^[10]

关键词 5-FU, fluorouracil AMED, Japan Agency for Medical Research and Development CHST15, carbohydrate sulfotransferase 15 CI, confidence interval CS-E, chondroitin sulfate E CTCAE, Common Terminology Criteria for Adverse Events Carbohydrate sulfotransferase 15 (CHST15)DCR, disease control rate DLT, dose-liming toxicity ECM, extracellular matrix EMT, epithelial mesenchymal transition EUS-FNI, endoscopic ultrasound-guided fine needle injection Endoscopic ultrasound-guided fine needle injection FAS, full analysis set GM-CSF, Granulocyte-macrophage colony-stimulating factor IQR, interquartile range IRB, Institutional Review Board LV, leucovorin MTD, maximum tolerated dose OS, overall survival PDAC, pancreatic ductal adenocarcinoma PFS, progression free survival STNM01 TEAE, treatment emergent adverse event TGF, transforming growth factor Tumor-infiltrating CD3+ and CD8+ T cells Unresectable pancreatic cancer nal-IRI, nanoliposomal irinotecan sCD44v6, soluble CD44 variant 6

DOI 10.1016/j.eclinm.2022.101731

PMID 36425867

发布时间 2023-01-12

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STNM01, the RNA oligonucleotide targeting carbohydrate sulfotransferase 15, as second-line therapy for chemotherapy-refractory patients with unresectable pancreatic cancer: An open label, phase I/IIa trial.

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STNM01, the RNA oligonucleotide targeting carbohydrate sulfotransferase 15, as second-line therapy for chemotherapy-refractory patients with unresectable pancreatic cancer: An open label, phase I/IIa trial.

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