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Tissue-Specific Human Extracellular Matrix Scaffolds Promote Pancreatic Tumour Progression and Chemotherapy Resistance.

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第一作者： Walid,Al-Akkad

第一单位： UCL Institute for Liver and Digestive Health, Royal Free Hospital, University College London, London NW3 2PF, UK.;Engitix Therapeutics, The Westworks, 195 Wood Lane, Shepherd's Bush, London W12 7FQ, UK.

作者： Walid,Al-Akkad ^[1] ; Pilar,Acedo ^[2] ; Maria-Giovanna,Vilia ^[1] ; Luca,Frenguelli ^[1] ; Alexander,Ney ^[2] ; Irene,Rodriguez-Hernandez ^[3] ; Peter L,Labib ^[2] ; Domenico,Tamburrino ^[4] ; Gabriele,Spoletini ^[4] ; Andrew R,Hall ^[5] ; Simone,Canestrari ^[2] ; Anna,Osnato ^[6] ; Jose,Garcia-Bernardo ^[7] ; Leinal,Sejour ^[8] ; Vessela,Vassileva ^[9] ; Ioannis S,Vlachos ^[8] ; Giuseppe,Fusai ^[4] ; Tu Vinh,Luong ^[5] ; Steven R,Whittaker ^[3] ; Stephen P,Pereira ^[2] ; Ludovic,Vallier ^[6] ; Massimo,Pinzani ^[2] ; Krista,Rombouts ^[2] ; Giuseppe,Mazza ^[1]

作者单位： UCL Institute for Liver and Digestive Health, Royal Free Hospital, University College London, London NW3 2PF, UK.;Engitix Therapeutics, The Westworks, 195 Wood Lane, Shepherd's Bush, London W12 7FQ, UK. ^[1] UCL Institute for Liver and Digestive Health, Royal Free Hospital, University College London, London NW3 2PF, UK. ^[2] Engitix Therapeutics, The Westworks, 195 Wood Lane, Shepherd's Bush, London W12 7FQ, UK. ^[3] Division of Surgery, Royal Free London NHS Foundation Trust, University College London, London NW3 2QG, UK. ^[4] UCL Institute for Liver and Digestive Health, Royal Free Hospital, University College London, London NW3 2PF, UK.;Sheila Sherlock Liver Centre, Royal Free London NHS Foundation Trust, London NW3 2PF, UK. ^[5] Wellcome Trust-MRC Cambridge Stem Cell Institute, Anne McLaren Laboratory, University of Cambridge, Cambridge CB2 0AW, UK.;Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire CB10 1RQ, UK. ^[6] Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire CB10 1RQ, UK. ^[7] Cancer Research Institute, HMS Initiative for RNA Medicine, Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA.;Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. ^[8] Department of Surgery and Cancer, Imperial College London, London SW7 2AZ, UK. ^[9]

关键词 3D cell-culture chemoresistance extracellular matrix liver metastasis pancreatic ductal adenocarcinoma tissue engineering tissue-specificity

医学主题词人类(Humans);细胞系, 肿瘤(Cell Line, Tumor);胰腺肿瘤(Pancreatic Neoplasms);癌, 胰腺管(Carcinoma, Pancreatic Ductal);胰腺(Pancreas);细胞外基质(Extracellular Matrix);腺癌(Adenocarcinoma)

DOI 10.3390/cells11223652

PMID 36429078

发布时间 2025-05-30

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