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Neurodegenerative Diseases: From Dysproteostasis, Altered Calcium Signalosome to Selective Neuronal Vulnerability to AAV-Mediated Gene Therapy.

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第一作者： Tam T,Quach

第一单位： Institute for Behavioral Medicine Research, Wexner Medical Center, The Ohio State University, Columbus, OH 43210, USA.;INSERM U1217/CNRS UMR5310, Université de Lyon, Université Claude Bernard Lyon 1, 69677 Lyon, France.

作者： Tam T,Quach ^[1] ; Harrison J,Stratton ^[2] ; Rajesh,Khanna ^[3] ; Sabrina,Mackey-Alfonso ^[4] ; Nicolas,Deems ^[4] ; Jérome,Honnorat ^[5] ; Kathrin,Meyer ^[6] ; Anne-Marie,Duchemin ^[7]

作者单位： Institute for Behavioral Medicine Research, Wexner Medical Center, The Ohio State University, Columbus, OH 43210, USA.;INSERM U1217/CNRS UMR5310, Université de Lyon, Université Claude Bernard Lyon 1, 69677 Lyon, France. ^[1] Department of Pharmacology, University of Arizona, Tucson, AZ 85716, USA. ^[2] Department of Molecular Pathobiology, New York University, New York, NY 10010, USA. ^[3] Institute for Behavioral Medicine Research, Wexner Medical Center, The Ohio State University, Columbus, OH 43210, USA. ^[4] INSERM U1217/CNRS UMR5310, Université de Lyon, Université Claude Bernard Lyon 1, 69677 Lyon, France.;French Reference Center on Paraneoplastic Neurological Syndromes and Autoimmune Encephalitis, Hospices Civils de Lyon, 69677 Lyon, France.;SynatAc Team, Institut NeuroMyoGène, 69677 Lyon, France. ^[5] The Research Institute of Nationwide Children Hospital, Columbus, OH 43205, USA.;Department of Pediatric, The Ohio State University, Columbus, OH 43210, USA. ^[6] Department of Psychiatry and Behavioral Health, The Ohio State University, Columbus, OH 43210, USA. ^[7]

关键词 CRMP3/DPYSL4 calcium signaling dendritic dystrophy dysproteostasis gene therapy neurodegeneration neuronal vulnerability

医学主题词人类(Humans);钙(Calcium);神经变性疾病(Neurodegenerative Diseases);神经元(Neurons);钙, 膳食(Calcium, Dietary)

DOI 10.3390/ijms232214188

PMID 36430666

发布时间 2022-12-13

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