CRISPR/SaCas9 mutagenesis of stromal interaction molecule 1 in proopiomelanocortin neurons increases glutamatergic excitability and protects against diet-induced obesity.

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作者： Jian,Qiu ^[1] ; Martha A,Bosch ^[2] ; Todd L,Stincic ^[2] ; Avery C,Hunker ^[3] ; Larry S,Zweifel ^[4] ; Oline K,Rønnekleiv ^[5] ; Martin J,Kelly ^[6]

作者单位： Department of Chemical Physiology and Biochemistry, Oregon Health & Science University, Portland, OR 97239, USA. Electronic address: qiuj@ohsu.edu. ^[1] Department of Chemical Physiology and Biochemistry, Oregon Health & Science University, Portland, OR 97239, USA. ^[2] Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA 98195, USA. ^[3] Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA 98195, USA; Department of Pharmacology, University of Washington, Seattle, WA 98195, USA. ^[4] Department of Chemical Physiology and Biochemistry, Oregon Health & Science University, Portland, OR 97239, USA; Division of Neuroscience, Oregon National Primate Research Center, Beaverton, OR 97006, USA. ^[5] Department of Chemical Physiology and Biochemistry, Oregon Health & Science University, Portland, OR 97239, USA; Division of Neuroscience, Oregon National Primate Research Center, Beaverton, OR 97006, USA. Electronic address: kellym@ohsu.edu. ^[6]

关键词 CRISPR/SaCas9 Glutamate High fat diet POMC STIM1 TRPC 5 channel

主题词动物(Animals);男(雄)性(Male);小鼠(Mice);钙(Calcium);诱变(Mutagenesis);神经元(Neurons);肥胖症(Obesity);前阿片黑素细胞皮质激素(Pro-Opiomelanocortin)

DOI 10.1016/j.molmet.2022.101645

PMID 36442744

发布时间 2023-04-28

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Molecular metabolism

2022年66卷

101645页

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CRISPR/SaCas9 mutagenesis of stromal interaction molecule 1 in proopiomelanocortin neurons increases glutamatergic excitability and protects against diet-induced obesity.

Molecular metabolism

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Molecular metabolism

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CRISPR/SaCas9 mutagenesis of stromal interaction molecule 1 in proopiomelanocortin neurons increases glutamatergic excitability and protects against diet-induced obesity.

Molecular metabolism

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Molecular metabolism

相关期刊

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