Neuroprotective efficacy of the bacterial metabolite, prodigiosin, against aluminium chloride-induced neurochemical alternations associated with Alzheimer's disease murine model: Involvement of Nrf2/HO-1/NF-κB signaling.

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第一作者： Khalaf F,Alsharif

第一单位： Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Taif University, Taif, Saudi Arabia.

作者： Khalaf F,Alsharif ^[1] ; Ashraf,Albrakati ^[2] ; Naif E,Al Omairi ^[3] ; Abdulraheem S,Almalki ^[4] ; Walaa,Alsanie ^[3] ; Zakaria Y,Abd Elmageed ^[5] ; Fahad,Alharthi ^[6] ; Hussam A,Althagafi ^[7] ; Abdullah A A,Alghamdi ^[8] ; Ibrahim Eid,Hassan ^[9] ; Ola A,Habotta ^[10] ; Maha S,Lokman ^[11] ; Rami B,Kassab ^[12] ; Rehab E,El-Hennamy ^[7]

作者单位： Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Taif University, Taif, Saudi Arabia. ^[1] Department of Human Anatomy, College of Medicine, Taif University, Taif, Saudi Arabia. ^[2] Department of Internal Medicine, College of Medicine, Taif University, Taif, Saudi Arabia. ^[3] Department of Chemistry, Faculty of Science, Taif University, Taif, Saudi Arabia. ^[4] Department of Pharmacology, Edward Via College of Osteopathic Medicine, University of Louisiana at Monroe, Monroe, Louisiana, USA. ^[5] Department of Biology, College of Science, Taif University, Taif, Saudi Arabia. ^[6] Department of Biology, Faculty of Science and Arts, Al-Baha University, Almakhwah, Al-Baha, Saudi Arabia. ^[7] Department of Biology, Faculty of Science, Al-Baha University, Al-Baha, Saudi Arabia. ^[8] Department of Physics, Faculty of Science, Helwan University, Cairo, Egypt. ^[9] Department of Physics, College of Science and Arts, Qassim University, Alnbhaniah, Saudi Arabia. ^[10] Department of Forensic Medicine and Toxicology, Faculty of Veterinary Medicine, Mansoura University, Mansoura, Egypt. ^[11] Biology Department, College of Science and Humanities, Prince Sattam bin Abdul Aziz University, Alkharj, Saudi Arabia. ^[12] Department of Zoology and Entomology, Faculty of Science, Helwan University, Cairo, Egypt. ^[13]

关键词 Alzheimer's disease Nrf2/NF-κB apoptosis oxidative stress and neuroinflammation prodigiosin