New Assay Reveals Vast Excess of Defective over Intact HIV-1 Transcripts in Antiretroviral Therapy-Suppressed Individuals.

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第一作者： Holly Anne,Martin

第一单位： Department of Medicine, University of California, San Francisco (UCSF), San Francisco, California, USA.;Department of Medicine, San Francisco Veterans Affairs Medical Center, San Francisco, California, USA.

作者： Holly Anne,Martin ^[1] ; Gayatri Nikhila,Kadiyala ^[1] ; Sushama,Telwatte ^[1] ; Adam,Wedrychowski ^[1] ; Tsui-Hua,Chen ^[2] ; Sara,Moron-Lopez ^[1] ; Doug,Arneson ^[3] ; Rebecca,Hoh ^[3] ; Steven,Deeks ^[3] ; Joseph,Wong ^[1] ; Steven A,Yukl ^[1]

作者单位： Department of Medicine, University of California, San Francisco (UCSF), San Francisco, California, USA.;Department of Medicine, San Francisco Veterans Affairs Medical Center, San Francisco, California, USA. ^[1] Department of Medicine, San Francisco Veterans Affairs Medical Center, San Francisco, California, USA. ^[2] Department of Medicine, University of California, San Francisco (UCSF), San Francisco, California, USA. ^[3]

关键词 HIV DNA HIV RNA HIV provirus HIV-1 defective infectious intact intact proviral DNA assay (IPDA)latent infection transcription transcriptional regulation viral replication

主题词人类(Humans);HIV感染(HIV Infections);HIV-1(HIV-1);原病毒(Proviruses);RNA, 病毒(RNA, Viral);病毒学(Virology)

DOI 10.1128/jvi.01605-22

PMID 36448806

发布时间 2023-05-31

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