Discovery and Optimization of Potent and Orally Available CTP Synthetase Inhibitors for Use in Treatment of Diseases Driven by Aberrant Immune Cell Proliferation.

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作者： Andrew,Novak ^[1] ; David,Laughton ^[1] ; Rebecca,Lane ^[1] ; Emma,Blackham ^[1] ; Jennifer,Thomas ^[1] ; Elli,Chatzopoulou ^[1] ; Joseph,Wrigglesworth ^[1] ; Abdul,Quddus ^[1] ; Saleh,Ahmed ^[1] ; David,Cousin ^[1] ; Lorna,Duffy ^[1] ; Nathalie,Dubois ^[1] ; John,Unitt ^[1] ; Katalin,Orban ^[1] ; Edward,Browne ^[1] ; Michelle,Ward ^[1] ; David,Mycock ^[1] ; Maria,Ieva ^[1] ; Nicholas,Bland ^[1] ; Pascal,George ^[2] ; Timothy,Bourne ^[2] ; Hélène,Asnagli ^[2] ; Louise,Birch ^[1] ; Geraint,Jones ^[1]

作者单位： Sygnature Discovery, BioCity, Pennyfoot Street, NottinghamNG1 1GF, U.K. ^[1] Step Pharma, 15 Rue Louis et Auguste Lumière, Saint Genis-Pouilly01 630, France. ^[2]

主题词动物(Animals);酶抑制剂(Enzyme Inhibitors);碳氮连接酶类(Carbon-Nitrogen Ligases);细胞增殖(Cell Proliferation);高通量筛选分析(High-Throughput Screening Assays)

DOI 10.1021/acs.jmedchem.2c01446

PMID 36449304

发布时间 2023-01-05

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