Sensitive HPLC-DMS/MS/MS method coupled with dispersive magnetic solid phase extraction followed by in situ derivatization for the simultaneous determination of multiplexing androgens and 17-hydroxyprogesterone in human serum and its application to patients with polycystic ovarian syndrome.

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作者： Xianhua,Zhang ^[1] ; Huiyu,Xu ^[2] ; Guoshuang,Feng ^[3] ; Li,Yang ^[1] ; Libo,Zhao ^[1] ; Rong,Li ^[4] ; Rongsheng,Zhao ^[5]

作者单位： Department of Pharmacy, Peking University Third Hospital, Beijing 100191, PR China; Therapeutic Drug Monitoring and Clinical Toxicology Center for Peking University, Beijing 100191, PR China. ^[1] Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing 100191, PR China; Key Laboratory of Assisted Reproduction, Peking University, Ministry of Education, Beijing 100191, PR China; National Clinical Research Center for Obstetrics and Gynecology, Peking University Third Hospital, Beijing 100191, PR China; Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology, Beijing 100191, PR China. ^[2] Big Data Center, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, PR China. ^[3] Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing 100191, PR China; Key Laboratory of Assisted Reproduction, Peking University, Ministry of Education, Beijing 100191, PR China; National Clinical Research Center for Obstetrics and Gynecology, Peking University Third Hospital, Beijing 100191, PR China; Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology, Beijing 100191, PR China. Electronic address: roseli001@sina.com. ^[4] Department of Pharmacy, Peking University Third Hospital, Beijing 100191, PR China; Therapeutic Drug Monitoring and Clinical Toxicology Center for Peking University, Beijing 100191, PR China. Electronic address: zhao_rongsheng@163.com. ^[5]

关键词 11-Oxygenated androgens Classic androgens DMSPE HPLC-DMS/MS/MS In situ derivatization PCOS