Moonlighting chaperone activity of the enzyme PqsE contributes to RhlR-controlled virulence of Pseudomonas aeruginosa.

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作者： Sebastian Roman,Borgert ^[1] ; Steffi,Henke ^[1] ; Florian,Witzgall ^[1] ; Stefan,Schmelz ^[1] ; Susanne,Zur Lage ^[1] ; Sven-Kevin,Hotop ^[2] ; Steffi,Stephen ^[2] ; Dennis,Lübken ^[3] ; Jonas,Krüger ^[4] ; Nicolas Oswaldo,Gomez ^[4] ; Marco,van Ham ^[5] ; Lothar,Jänsch ^[5] ; Markus,Kalesse ^[3] ; Andreas,Pich ^[6] ; Mark,Brönstrup ^[2] ; Susanne,Häussler ^[4] ; Wulf,Blankenfeldt ^[7]

作者单位： Department Structure and Function of Proteins, Helmholtz Centre for Infection Research, Inhoffenstr. 7, 38124, Braunschweig, Germany. ^[1] Department Chemical Biology, Helmholtz Centre for Infection Research, Inhoffenstr. 7, 38124, Braunschweig, Germany. ^[2] Institute of Organic Chemistry, Leibniz University Hannover, Schneiderberg 1B, 30167, Hannover, Germany. ^[3] Department Molecular Bacteriology, Helmholtz Centre for Infection Research, Inhoffenstr. 7, 38124, Braunschweig, Germany. ^[4] Cellular Proteomics, Helmholtz Centre for Infection Research, Inhoffenstr. 7, 38124, Braunschweig, Germany. ^[5] Institute for Toxicology, Core Facility Proteomics, Hannover Medical School, Carl-Neuberg-Str. 1, 30625, Hannover, Germany. ^[6] Department Structure and Function of Proteins, Helmholtz Centre for Infection Research, Inhoffenstr. 7, 38124, Braunschweig, Germany. wulf.blankenfeldt@helmholtz-hzi.de. ^[7] Institute for Biochemistry, Biotechnology and Bioinformatics, Technische Universität Braunschweig, Spielmannstr. 7, 38106, Braunschweig, Germany. wulf.blankenfeldt@helmholtz-hzi.de. ^[8]

主题词毒力(Virulence);铜绿假单胞菌(Pseudomonas aeruginosa);蛋白质折叠(Protein Folding);转录因子(Transcription Factors)

DOI 10.1038/s41467-022-35030-w

PMID 36456567

发布时间 2023-10-10

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