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Identification of low and very high-risk patients with non-WNT/non-SHH medulloblastoma by improved clinico-molecular stratification of the HIT2000 and I-HIT-MED cohorts.

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作者单位: Department for Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Martinistr. 52, 20246, Hamburg, Germany. m.mynarek@uke.de. [1] Mildred Scheel Cancer Career Center HaTriCS4, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. m.mynarek@uke.de. [2] Department for Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Martinistr. 52, 20246, Hamburg, Germany. [3] Hopp Children's Cancer Center Heidelberg (KiTZ), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany. [4] Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) and German Consortium for Translational Cancer Research (DKTK), Heidelberg, Germany. [5] Department of Pediatric Hematology and Oncology, Heidelberg University Hospital, Heidelberg, Germany. [6] Division of Pediatric Glioma Research, German Cancer Research Center (DKFZ) and German Consortium for Translational Cancer Research (DKTK), Heidelberg, Germany. [7] Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center (DKFZ) and German Consortium for Translational Cancer Research (DKTK), Heidelberg, Germany. [8] Charité-Universitätsmedizin Berlin, Berlin, Germany. [9] Institute of Neuropathology, Brain Tumor Reference Center of the German Society for Neuropathology and Neuroanatomy (DGNN), University of Bonn Medical Center, Bonn, Germany. [10] Mildred Scheel Cancer Career Center HaTriCS4, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. [11] Research Institute Children's Cancer Center Hamburg, Hamburg, Germany. [12] Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands. [13] Department of Neuropathology, Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany. [14] Clinical Cooperation Unit Neuropathology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany. [15] Department of Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. [16] Division of Pediatric Hematology and Oncology, Department of Pediatrics and Adolescent Medicine, Medical University of Graz, Graz, Austria. [17] Department of Oncology, University Children's Hospital, Zurich, Switzerland. [18] Children's Research Centre, University Children's Hospital, Zurich, Switzerland. [19] Hopp Children's Cancer Center Heidelberg (KiTZ), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany. t.milde@kitz-heidelberg.de. [20] Department of Pediatric Hematology and Oncology, Heidelberg University Hospital, Heidelberg, Germany. t.milde@kitz-heidelberg.de. [21] Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center (DKFZ) and German Consortium for Translational Cancer Research (DKTK), Heidelberg, Germany. t.milde@kitz-heidelberg.de. [22]
DOI 10.1007/s00401-022-02522-4
PMID 36459208
发布时间 2023-03-07
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