Long noncoding RNA HCG18 Promotes Extracellular Matrix Degradation of Nucleus Pulposus Cells in Intervertebral Disc Degeneration by Regulating the miR-4306/EPAS1 Axis.

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作者： Sheng,Cao ^[1] ; Yuan,Ma ^[2] ; Houzhi,Yang ^[3] ; Gan,Luo ^[3] ; Haiyang,Cheng ^[3] ; Xin,Jin ^[4] ; Tianwei,Sun ^[5]

作者单位： Tianjin Medical University, Tianjin, China; Department of Spinal Surgery, Affiliated Hospital of Chengde Medical University, Chengde, Hebei, China. ^[1] Tianjin Medical University, Tianjin, China; Department of Orthopedic, Nanyang Central Hospital, Nanyang, Henan, China. ^[2] Tianjin Medical University, Tianjin, China. ^[3] School of Medicine, Nankai University, Tianjin, China. ^[4] Tianjin Medical University, Tianjin, China; Department of Spinal Surgery, Tianjin Union Medical Center, Tianjin, China. Electronic address: suntianwei@umc.net.cn. ^[5]

关键词 EPAS1 Extracellular matrix degradation Intervertebral disc degeneration MIR4306 lncRNA HCG18

主题词人类(Humans);细胞外基质(Extracellular Matrix);白细胞介素1β(Interleukin-1beta);微RNAs(MicroRNAs)

DOI 10.1016/j.wneu.2022.11.126

PMID 36460200

发布时间 2024-06-20

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