Integration of genome-scale data identifies candidate sleep regulators.

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第一作者： Yin Yeng,Lee

第一单位： Divisions of Human Genetics and Immunobiology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 45229, USA.

作者： Yin Yeng,Lee ^[1] ; Mehari,Endale ^[2] ; Gang,Wu ^[3] ; Marc D,Ruben ^[1] ; Lauren J,Francey ^[1] ; Andrew R,Morris ^[1] ; Natalie Y,Choo ^[3] ; Ron C,Anafi ^[4] ; David F,Smith ^[5] ; Andrew C,Liu ^[4] ; John B,Hogenesch ^[6]

作者单位： Divisions of Human Genetics and Immunobiology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 45229, USA. ^[1] Department of Pharmacology and Systems Physiology, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA. ^[2] Department of Physiology and Aging, University of Florida College of Medicine, Gainesville, FL 32610, USA. ^[3] Division of Pediatric Otolaryngology-Head and Neck Surgery, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA. ^[4] Department of Medicine, Chronobiology and Sleep Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. ^[5] Division of Pulmonary Medicine and the Sleep Center, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA. ^[6] Center for Circadian Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA. ^[7] Department of Otolaryngology - Head and Neck Surgery, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA. ^[8]

关键词 genetics genome-scale data integration machine learning sleep regulation

主题词动物(Animals);小鼠(Mice);昼夜节律(Circadian Rhythm);基因表达调控(Gene Expression Regulation);NF-κB(NF-kappa B);睡眠(Sleep);睡眠剥夺(Sleep Deprivation)

DOI 10.1093/sleep/zsac279

PMID 36462188

发布时间 2023-12-04

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