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FXR inhibition may protect from SARS-CoV-2 infection by reducing ACE2.

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作者: Teresa,Brevini [1] ; Mailis,Maes [2] ; Gwilym J,Webb [3] ; Binu V,John [4] ; Claudia D,Fuchs [5] ; Gustav,Buescher [6] ; Lu,Wang [7] ; Chelsea,Griffiths [7] ; Marnie L,Brown [7] ; William E,Scott [7] ; Pehuén,Pereyra-Gerber [2] ; William T H,Gelson [8] ; Stephanie,Brown [9] ; Scott,Dillon [9] ; Daniele,Muraro [10] ; Jo,Sharp [11] ; Megan,Neary [11] ; Helen,Box [11] ; Lee,Tatham [11] ; James,Stewart [12] ; Paul,Curley [11] ; Henry,Pertinez [11] ; Sally,Forrest [2] ; Petra,Mlcochova [13] ; Sagar S,Varankar [9] ; Mahnaz,Darvish-Damavandi [14] ; Victoria L,Mulcahy [15] ; Rhoda E,Kuc [16] ; Thomas L,Williams [16] ; James A,Heslop [9] ; Davide,Rossetti [9] ; Olivia C,Tysoe [17] ; Vasileios,Galanakis [9] ; Marta,Vila-Gonzalez [9] ; Thomas W M,Crozier [2] ; Johannes,Bargehr [18] ; Sanjay,Sinha [19] ; Sara S,Upponi [20] ; Corrina,Fear [21] ; Lisa,Swift [21] ; Kourosh,Saeb-Parsy [22] ; Susan E,Davies [23] ; Axel,Wester [24] ; Hannes,Hagström [24] ; Espen,Melum [25] ; Darran,Clements [9] ; Peter,Humphreys [9] ; Jo,Herriott [11] ; Edyta,Kijak [11] ; Helen,Cox [11] ; Chloe,Bramwell [11] ; Anthony,Valentijn [11] ; Christopher J R,Illingworth [26] ; UK-PBC Consortium [27] ; Bassam,Dahman [27] ; Dustin R,Bastaich [4] ; Raphaella D,Ferreira [28] ; Thomas,Marjot [28] ; Eleanor,Barnes [29] ; Andrew M,Moon [29] ; Alfred S,Barritt [30] ; Ravindra K,Gupta [2] ; Stephen,Baker [16] ; Anthony P,Davenport [31] ; Gareth,Corbett [32] ; Vassilis G,Gorgoulis [14] ; Simon J A,Buczacki [33] ; Joo-Hyeon,Lee [34] ; Nicholas J,Matheson [5] ; Michael,Trauner [7] ; Andrew J,Fisher [22] ; Paul,Gibbs [22] ; Andrew J,Butler [35] ; Christopher J E,Watson [36] ; George F,Mells [2] ; Gordon,Dougan [11] ; Andrew,Owen [6] ; Ansgar W,Lohse [37] ; Ludovic,Vallier [38] ; Fotios,Sampaziotis
作者单位: Wellcome-MRC Cambridge Stem Cell Institute, Cambridge, UK. tb647@cam.ac.uk. [1] Cambridge Institute of Therapeutic Immunology & Infectious Disease (CITIID), Department of Medicine, University of Cambridge, Cambridge, UK. [2] Cambridge Liver Unit, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK. [3] Division of Gastroenterology and Hepatology, University of Miami and Miami VA Health System, Miami, FL, USA. [4] Hans Popper Laboratory of Molecular Hepatology, Division of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria. [5] Department of Medicine, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany. [6] Transplant and Regenerative Medicine Laboratory, Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK. [7] Cambridge Liver Unit, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.;Department of Medicine, University of Cambridge, Cambridge, UK. [8] Wellcome-MRC Cambridge Stem Cell Institute, Cambridge, UK. [9] Wellcome Sanger Institute, Hinxton, UK. [10] Centre of Excellence in Long-acting Therapeutics (CELT), Department of Pharmacology and Therapeutics, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK. [11] Department of Infection Biology and Microbiomes, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, UK. [12] Cambridge Institute of Therapeutic Immunology & Infectious Disease (CITIID), Department of Medicine, University of Cambridge, Cambridge, UK.;Division of Gastroenterology and Hepatology, University of Miami and Miami VA Health System, Miami, FL, USA. [13] Wellcome-MRC Cambridge Stem Cell Institute, Cambridge, UK.;Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK. [14] Academic Department of Medical Genetics, University of Cambridge, Cambridge, UK. [15] Experimental Medicine and Immunotherapeutics, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK. [16] Wellcome-MRC Cambridge Stem Cell Institute, Cambridge, UK.;Department of Surgery, University of Cambridge and NIHR Cambridge Biomedical Research Centre, Cambridge, UK. [17] Wellcome-MRC Cambridge Stem Cell Institute, Cambridge, UK.;Department of Medicine, University of Cambridge, Cambridge, UK.;Division of Cardiovascular Medicine, University of Cambridge, Cambridge, UK. [18] Wellcome-MRC Cambridge Stem Cell Institute, Cambridge, UK.;Division of Cardiovascular Medicine, University of Cambridge, Cambridge, UK. [19] Department of Radiology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK. [20] Department of Surgery, University of Cambridge and NIHR Cambridge Biomedical Research Centre, Cambridge, UK. [21] Department of Surgery, University of Cambridge and NIHR Cambridge Biomedical Research Centre, Cambridge, UK.;Roy Calne Transplant Unit, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK. [22] Department of Histopathology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK. [23] Department of Medicine, Huddinge, Karolinska Institutet, Stockholm, Sweden. [24] Norwegian PSC Research Center, Department of Transplantation Medicine, Division of Surgery, Inflammatory Diseases and Transplantation, Oslo University Hospital, Rikshospitalet, Oslo, Norway.;Research Institute of Internal Medicine, Division of Surgery, Inflammatory Diseases and Transplantation, Oslo University Hospital, Rikshospitalet, Oslo, Norway.;Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway.;Section of Gastroenterology, Department of Transplantation Medicine, Division of Surgery, Inflammatory Diseases and Transplantation, Oslo University Hospital, Rikshospitalet, Oslo, Norway.;Hybrid Technology Hub Centre of Excellence, Institute of Basic Medical Sciences, Faculty of Medicine, University of Oslo, Oslo, Norway. [25] MRC-University of Glasgow Centre for Virus Research, Glasgow, UK.;Department of Applied Mathematics and Theoretical Physics, University of Cambridge, Cambridge, UK. [26] Department of Health Behavior and Policy, Virginia Commonwealth University, Richmond, VA, USA. [27] Oxford Liver Unit, Translational Gastroenterology Unit, Oxford University Hospitals NHS Foundation Trust, University of Oxford, Oxford, UK. [28] Division of Gastroenterology and Hepatology, University of North Carolina, Chapel Hill, NC, USA. [29] Cambridge Institute of Therapeutic Immunology & Infectious Disease (CITIID), Department of Medicine, University of Cambridge, Cambridge, UK.;Department of Medicine, University of Cambridge, Cambridge, UK. [30] Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK. [31] Department of Histology and Embryology, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.;Ninewells Hospital and Medical School, University of Dundee, Dundee, UK.;Biomedical Research Foundation, Academy of Athens, Athens, Greece. [32] Wellcome-MRC Cambridge Stem Cell Institute, Cambridge, UK.;Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK. [33] Cambridge Institute of Therapeutic Immunology & Infectious Disease (CITIID), Department of Medicine, University of Cambridge, Cambridge, UK.;Department of Medicine, University of Cambridge, Cambridge, UK.;Division of Gastroenterology and Hepatology, University of North Carolina, Chapel Hill, NC, USA.;NHS Blood and Transplant, Cambridge, UK. [34] Department of Surgery, University of Cambridge and NIHR Cambridge Biomedical Research Centre, Cambridge, UK.;Roy Calne Transplant Unit, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.;National Institute of Health Research (NIHR) Cambridge Biomedical Research Centre, and the NIHR Blood and Transplant Research Unit (BTRU) at the University of Cambridge in collaboration with Newcastle University and in partnership with NHS Blood and Transplant (NHSBT), Cambridge, UK. [35] Cambridge Liver Unit, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.;Academic Department of Medical Genetics, University of Cambridge, Cambridge, UK. [36] Wellcome-MRC Cambridge Stem Cell Institute, Cambridge, UK. ludovic.vallier@bih-charite.de.;Wellcome Sanger Institute, Hinxton, UK. ludovic.vallier@bih-charite.de.;Berlin Institute of Health (BIH), BIH Centre for Regenerative Therapies (BCRT), Charité-Universitätsmedizin Berlin, Berlin, Germany. ludovic.vallier@bih-charite.de.;Max Planck Institute for Molecular Genetics, Berlin, Germany. ludovic.vallier@bih-charite.de. [37] Wellcome-MRC Cambridge Stem Cell Institute, Cambridge, UK. fs347@cam.ac.uk.;Cambridge Liver Unit, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK. fs347@cam.ac.uk.;Department of Medicine, University of Cambridge, Cambridge, UK. fs347@cam.ac.uk. [38]
DOI 10.1038/s41586-022-05594-0
PMID 36470304
发布时间 2025-01-04
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