第一单位：
Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA. karagam@broadinstitute.org.;Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA. karagam@broadinstitute.org.;Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA. karagam@broadinstitute.org.;Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA. karagam@broadinstitute.org.
作者：
Krishna G,Aragam [1]
;
Tao,Jiang [2]
;
Anuj,Goel [3]
;
Stavroula,Kanoni [4]
;
Brooke N,Wolford [5]
;
Deepak S,Atri [6]
;
Elle M,Weeks [7]
;
Minxian,Wang [8]
;
George,Hindy [9]
;
Wei,Zhou [10]
;
Christopher,Grace [3]
;
Carolina,Roselli [11]
;
Nicholas A,Marston [12]
;
Frederick K,Kamanu [12]
;
Ida,Surakka [13]
;
Loreto Muñoz,Venegas [14]
;
Paul,Sherliker [15]
;
Satoshi,Koyama [16]
;
Kazuyoshi,Ishigaki [17]
;
Bjørn O,Åsvold [18]
;
Michael R,Brown [19]
;
Ben,Brumpton [20]
;
Paul S,de Vries [19]
;
Olga,Giannakopoulou [4]
;
Panagiota,Giardoglou [21]
;
Daniel F,Gudbjartsson [22]
;
Ulrich,Güldener [23]
;
Syed M Ijlal,Haider [14]
;
Anna,Helgadottir [24]
;
Maysson,Ibrahim [25]
;
Adnan,Kastrati [26]
;
Thorsten,Kessler [26]
;
Theodosios,Kyriakou [27]
;
Tomasz,Konopka [4]
;
Ling,Li [23]
;
Lijiang,Ma [28]
;
Thomas,Meitinger [29]
;
Sören,Mucha [14]
;
Matthias,Munz [14]
;
Federico,Murgia [25]
;
Jonas B,Nielsen [30]
;
Markus M,Nöthen [31]
;
Shichao,Pang [23]
;
Tobias,Reinberger [14]
;
Gavin,Schnitzler [11]
;
Damian,Smedley [4]
;
Gudmar,Thorleifsson [24]
;
Moritz,von Scheidt [26]
;
Jacob C,Ulirsch [32]
;
Biobank Japan [33]
;
EPIC-CVD [7]
;
David O,Arnar [7]
;
Noël P,Burtt [34]
;
Maria C,Costanzo [16]
;
Jason,Flannick [7]
;
Kaoru,Ito [35]
;
Dong-Keun,Jang [36]
;
Yoichiro,Kamatani [37]
;
Amit V,Khera [38]
;
Issei,Komuro [39]
;
Iftikhar J,Kullo [40]
;
Luca A,Lotta [41]
;
Christopher P,Nelson [33]
;
Robert,Roberts [42]
;
Gudmundur,Thorgeirsson [40]
;
Unnur,Thorsteinsdottir [39]
;
Thomas R,Webb [43]
;
Aris,Baras [44]
;
Johan L M,Björkegren [21]
;
Eric,Boerwinkle [24]
;
George,Dedoussis [20]
;
Hilma,Holm [45]
;
Kristian,Hveem [19]
;
Olle,Melander [45]
;
Alanna C,Morrison [46]
;
Marju,Orho-Melander [47]
;
Loukianos S,Rallidis [12]
;
Arno,Ruusalepp [42]
;
Marc S,Sabatine [48]
;
Kari,Stefansson [49]
;
Pierre,Zalloua [3]
;
Patrick T,Ellinor [50]
;
Martin,Farrall [12]
;
John,Danesh [51]
;
Christian T,Ruff [25]
;
Hilary K,Finucane [25]
;
Jemma C,Hopewell [52]
;
Robert,Clarke [14]
;
Rajat M,Gupta [53]
;
Jeanette,Erdmann [26]
;
Nilesh J,Samani [3]
;
Heribert,Schunkert [54]
;
Hugh,Watkins [55]
;
Cristen J,Willer [56]
;
Panos,Deloukas [57]
;
Sekar,Kathiresan ;
Adam S,Butterworth ;
CARDIoGRAMplusC4D Consortium
作者单位：
Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA. karagam@broadinstitute.org.;Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA. karagam@broadinstitute.org.;Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA. karagam@broadinstitute.org.;Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA. karagam@broadinstitute.org.
[1]
BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
[2]
Radcliffe Department of Medicine, Division of Cardiovascular Medicine, University of Oxford, Oxford, UK.;Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.
[3]
William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
[4]
Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA.
[5]
Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA.;Divisions of Cardiovascular Medicine and Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
[6]
Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
[7]
Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA.;Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
[8]
Department of Population Medicine, Qatar University College of Medicine, Doha, Qatar.
[9]
Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.;Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA.;Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.;Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
[10]
Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
[11]
TIMI Study Group, Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
[12]
Department of Internal Medicine, Division of Cardiology, University of Michigan, Ann Arbor, MI, USA.
[13]
Institute for Cardiogenetics, University of Lübeck, Lübeck, Germany.;German Research Center for Cardiovascular Research (DZHK), Partner Site Hamburg/Lübeck/Kiel, Lübeck, Germany.
[14]
Medical Research Council Population Health Research Unit, CTSU-Nuffield Department of Population Health, Medical Sciences Division, University of Oxford, Oxford, UK.
[15]
Laboratory for Cardiovascular Genomics and Informatics, RIKEN Center for Integrative Medical Sciences, Tsurumi-ku, Yokohama, Japan.
[16]
Laboratory for Statistical and Translational Genetics, RIKEN Center for Integrative Medical Sciences, Tsurumi-ku, Yokohama, Japan.
[17]
Department of Public Health and Nursing, K.G. Jebsen Center for Genetic Epidemiology, Norwegian University of Science and Technology, NTNU, Trondheim, Norway.;HUNT Research Centre, Norwegian University of Science and Technology, Levanger, Norway.;Department of Endocrinology, Clinic of Medicine, St. Olavs Hospital, Trondheim, Norway.
[18]
Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA.
[19]
Department of Public Health and Nursing, K.G. Jebsen Center for Genetic Epidemiology, Norwegian University of Science and Technology, NTNU, Trondheim, Norway.;HUNT Research Centre, Norwegian University of Science and Technology, Levanger, Norway.
[20]
Department of Nutrition-Dietetics, School of Health Science and Education, Harokopio University, Athens, Greece.
[21]
deCODE Genetics/Amgen, Inc., Reykjavik, Iceland.;School of Engineering and Natural Sciences, University of Iceland, Reykjavik, Iceland.
[22]
German Heart Centre Munich, Department of Cardiology, Technical University of Munich, Munich, Germany.
[23]
deCODE Genetics/Amgen, Inc., Reykjavik, Iceland.
[24]
CTSU-Nuffield Department of Population Health, Medical Sciences Division, University of Oxford, Oxford, UK.
[25]
German Heart Centre Munich, Department of Cardiology, Technical University of Munich, Munich, Germany.;German Research Center for Cardiovascular Research (DZHK e.V.), Partner Site Munich Heart Alliance, Munich, Germany.
[26]
Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.
[27]
Department of Genetics and Genomic Science, Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.;The Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
[28]
German Research Center for Cardiovascular Research (DZHK e.V.), Partner Site Munich Heart Alliance, Munich, Germany.;Institute of Human Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.;Klinikum Rechts der Isar, Institute of Human Genetics, Technical University of Munich, Munich, Germany.
[29]
Department of Internal Medicine, Division of Cardiology, University of Michigan, Ann Arbor, MI, USA.;Department of Public Health and Nursing, K.G. Jebsen Center for Genetic Epidemiology, Norwegian University of Science and Technology, NTNU, Trondheim, Norway.
[30]
School of Medicine and University Hospital Bonn, Institute of Human Genetics, University of Bonn, Bonn, Germany.
[31]
Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.;Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.;Program in Biological and Biomedical Sciences, Harvard Medical School, Boston, MA, USA.
[32]
deCODE Genetics/Amgen, Inc., Reykjavik, Iceland.;Faculty of Medicine, University of Iceland, Reykjavik, Iceland.;Department of Internal Medicine, Division of Cardiology, Landspitali-National University Hospital of Iceland, Hringbraut, Reykjavik, Iceland.
[33]
Division of Genetics and Genomics, Boston Children's Hospital, Boston, MA, USA.
[34]
Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Tokyo, Japan.
[35]
Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.;Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA.;Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
[36]
Department of Cardiovascular Medicine, The University of Tokyo, Tokyo, Japan.
[37]
Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, USA.
[38]
Regeneron Genetics Center, Regeneron Pharmaceuticals, Tarrytown, NY, USA.
[39]
Department of Cardiovascular Sciences and NIHR Leicester Biomedical Research Centre, University of Leicester, Glenfield Hospital, Leicester, UK.
[40]
Cardiovascular Genomics and Genetics, University of Arizona College of Medicin, Phoenix, AZ, USA.
[41]
deCODE Genetics/Amgen, Inc., Reykjavik, Iceland.;Faculty of Medicine, University of Iceland, Reykjavik, Iceland.
[42]
Department of Genetics and Genomic Sciences, Institute of Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.;Integrated Cardio Metabolic Centre, Karolinska Institutet, Karolinska Universitetssjukhuset, Huddinge, Sweden.;Clinical Gene Networks AB, Stockholm, Sweden.
[43]
Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA.;Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA.
[44]
Department of Clinical Sciences in Malmö, Lund University, Malmö, Sweden.
[45]
Second Department of Cardiology, Medical School, National and Kapodistrian University of Athens, University General Hospital Attikon, Athens, Greece.
[46]
Department of Cardiac Surgery, Tartu University Hospital and Institute of Clinical Medicine, Tartu University, Tartu, Estonia.
[47]
Harvard T.H.Chan School of Public Health, Boston, MA, USA.;College of Medicine and Health Sciences, Khalifa University, Abu Dhabi, UAE.
[48]
Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA.;Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
[49]
BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.;National Institute for Health and Care Research Cambridge Biomedical Research Centre, Cambridge University Hospitals, Cambridge, UK.;The National Institute for Health and Care Research Blood and Transplant Unit (NIHR BTRU) in Donor Health and Genomics, University of Cambridge, Cambridge, UK.;Human Genetics, Wellcome Sanger Institute, Saffron Walden, UK.;Health Data Research UK Cambridge, Wellcome Genome Campus and University of Cambridge, Cambridge, UK.;British Heart Foundation Centre of Research Excellence, Division of Cardiovascular Medicine, Addenbrooke's Hospital, Cambridge, UK.
[50]
Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.;Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.;Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
[51]
Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA.;Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.;Divisions of Cardiovascular Medicine and Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
[52]
Faculty of Medicine, University of Iceland, Reykjavik, Iceland.
[53]
Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA.;Department of Internal Medicine, Division of Cardiology, University of Michigan, Ann Arbor, MI, USA.;Department of Human Genetics, University of Michigan, Ann Arbor, MI, USA.
[54]
William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.;Princess Al-Jawhara Al-Brahim Centre of Excellence in Research of Hereditary Disorders (PACER-HD), King Abdulaziz University, Jeddah, Saudi Arabia.
[55]
Verve Therapeutics, Cambridge, MA, USA.
[56]
BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK. asb38@medschl.cam.ac.uk.;National Institute for Health and Care Research Cambridge Biomedical Research Centre, Cambridge University Hospitals, Cambridge, UK. asb38@medschl.cam.ac.uk.;The National Institute for Health and Care Research Blood and Transplant Unit (NIHR BTRU) in Donor Health and Genomics, University of Cambridge, Cambridge, UK. asb38@medschl.cam.ac.uk.;Health Data Research UK Cambridge, Wellcome Genome Campus and University of Cambridge, Cambridge, UK. asb38@medschl.cam.ac.uk.;British Heart Foundation Centre of Research Excellence, Division of Cardiovascular Medicine, Addenbrooke's Hospital, Cambridge, UK. asb38@medschl.cam.ac.uk.
[57]
DOI
10.1038/s41588-022-01233-6
PMID
36474045
发布时间
2026-03-07
换一批
