Yap governs a lineage-specific neuregulin1 pathway-driven adaptive resistance to RAF kinase inhibitors.

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作者： Maria E R,Garcia-Rendueles ^[1] ; Gnana,Krishnamoorthy ^[2] ; Mahesh,Saqcena ^[3] ; Adrian,Acuña-Ruiz ^[3] ; Giovanna,Revilla ^[3] ; Elisa,de Stanchina ^[3] ; Jeffrey A,Knauf ^[4] ; Rona,Lester ^[3] ; Bin,Xu ^[5] ; Ronald A,Ghossein ^[3] ; James A,Fagin ^[6]

作者单位： Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA. mariaelena.rodriguez@imdea.org. ^[1] IMDEA Food Institute, Madrid, Spain. mariaelena.rodriguez@imdea.org. ^[2] Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA. ^[3] Antitumor Assessment Core Facility, Memorial Sloan Kettering Cancer Center, New York, NY, USA. ^[4] Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA. ^[5] Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA. ^[6] Weill-Cornell Medical College, New York, NY, USA. ^[7] Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA. faginj@mskcc.org. ^[8] Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA. faginj@mskcc.org. ^[9] Weill-Cornell Medical College, New York, NY, USA. faginj@mskcc.org. ^[10]

关键词 BRAF Dependency HER2 HER3 Hippo Lapatinib NRG1 Resistance Thyroid cancer Vemurafenib YAP

主题词人类(Humans);动物(Animals);小鼠(Mice);甲状腺肿瘤(Thyroid Neoplasms);raf激酶类(raf Kinases)

DOI 10.1186/s12943-022-01676-9

PMID 36476495

发布时间 2023-07-01

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准确一般字义偏差语意偏离译文作用小提交