首页> Cancer immunology research> Intratumoral Gene Transfer of mRNAs Encoding IL12 in Combination with Decoy-Resistant IL18 Improves Local and Systemic Antitumor Immunity.

Intratumoral Gene Transfer of mRNAs Encoding IL12 in Combination with Decoy-Resistant IL18 Improves Local and Systemic Antitumor Immunity.

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第一作者： Assunta,Cirella

第一单位： Program of Immunology and Immunotherapy, Cima Universidad de Navarra, Pamplona, Spain.;Navarra Institute for Health Research (IDISNA), Pamplona, Spain.

作者： Assunta,Cirella ^[1] ; Elixabet,Bolaños ^[1] ; Claudia Augusta,Di Trani ^[1] ; Carlos E,de Andrea ^[2] ; Sandra,Sánchez-Gregorio ^[1] ; Iñaki,Etxeberria ^[1] ; Jose,Gonzalez-Gomariz ^[1] ; Irene,Olivera ^[1] ; Davide,Brocco ^[3] ; Javier,Glez-Vaz ^[1] ; Carlos,Luri-Rey ^[1] ; Arantza,Azpilikueta ^[1] ; Inmaculada,Rodríguez ^[1] ; Myriam,Fernandez-Sendín ^[1] ; Josune,Egea ^[1] ; Iñaki,Eguren ^[1] ; Miguel F,Sanmamed ^[4] ; Belen,Palencia ^[5] ; Alvaro,Teijeira ^[6] ; Pedro,Berraondo ^[6] ; Ignacio,Melero ^[7]

作者单位： Program of Immunology and Immunotherapy, Cima Universidad de Navarra, Pamplona, Spain.;Navarra Institute for Health Research (IDISNA), Pamplona, Spain. ^[1] Navarra Institute for Health Research (IDISNA), Pamplona, Spain.;Department of Pathology, Clínica Universidad de Navarra, University of Navarra, Pamplona, Spain.;Department of Anatomy, Physiology and Pathology, University of Navarra, Pamplona, Spain.;Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Madrid, Spain. ^[2] Department of Pharmacy, University "G. D'Annunzio" Chieti-Pescara, Chieti, Italy. ^[3] Program of Immunology and Immunotherapy, Cima Universidad de Navarra, Pamplona, Spain.;Navarra Institute for Health Research (IDISNA), Pamplona, Spain.;Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Madrid, Spain.;Department of Oncology, Clinica Universidad de Navarra, Madrid, Spain. ^[4] Program of Immunology and Immunotherapy, Cima Universidad de Navarra, Pamplona, Spain. ^[5] Program of Immunology and Immunotherapy, Cima Universidad de Navarra, Pamplona, Spain.;Navarra Institute for Health Research (IDISNA), Pamplona, Spain.;Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Madrid, Spain. ^[6] Program of Immunology and Immunotherapy, Cima Universidad de Navarra, Pamplona, Spain.;Navarra Institute for Health Research (IDISNA), Pamplona, Spain.;Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Madrid, Spain.;Department of Oncology, Clinica Universidad de Navarra, Madrid, Spain.;Department of Immunology and Immunotherapy, Clínica Universidad de Navarra, Pamplona, Spain. ^[7]

医学主题词动物(Animals);小鼠(Mice);白细胞介素18(Interleukin-18);肿瘤(Neoplasms);CD8阳性T淋巴细胞(CD8-Positive T-Lymphocytes);免疫疗法(Immunotherapy);白细胞介素12(Interleukin-12)

DOI 10.1158/2326-6066.CIR-22-0373

PMID 36478221

发布时间 2023-03-17

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Cancer immunology research

2023年11卷2期

184-198页

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Cancer immunology research

2023年11卷2期

184-198页

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Intratumoral Gene Transfer of mRNAs Encoding IL12 in Combination with Decoy-Resistant IL18 Improves Local and Systemic Antitumor Immunity.

Cancer immunology research

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Intratumoral Gene Transfer of mRNAs Encoding IL12 in Combination with Decoy-Resistant IL18 Improves Local and Systemic Antitumor Immunity.

Cancer immunology research

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Cancer immunology research

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