Epigenetic-related gene mutations serve as potential biomarkers for immune checkpoint inhibitors in microsatellite-stable colorectal cancer.

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作者： Chao,Liu ^[1] ; Huiting,Xiao ^[2] ; Luying,Cui ^[1] ; Lin,Fang ^[1] ; Shuling,Han ^[1] ; Yuli,Ruan ^[1] ; Wenyuan,Zhao ^[2] ; Yanqiao,Zhang ^[3]

作者单位： Department of Gastrointestinal Medical Oncology, Harbin Medical University Cancer Hospital, Harbin, China.;Clinical Research Center for Colorectal Cancer in Heilongjiang, Harbin Medical University Cancer Hospital, Harbin, China.;Key Laboratory of Tumor Immunology in Heilongjiang, Harbin Medical University Cancer Hospital, Harbin, China. ^[1] College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China. ^[2] Department of Gastrointestinal Medical Oncology, Harbin Medical University Cancer Hospital, Harbin, China.;Clinical Research Center for Colorectal Cancer in Heilongjiang, Harbin Medical University Cancer Hospital, Harbin, China.;Key Laboratory of Tumor Immunology in Heilongjiang, Harbin Medical University Cancer Hospital, Harbin, China.;Translational Medicine Research and Cooperation Center of Northern China, Heilongjiang Academy of Medical Sciences, Harbin, China. ^[3]

关键词 biomarker colorectal cancer epigenetic-related gene mutations immune checkpoint inhibitor therapy microsatellite-stable

主题词人类(Humans);后成说, 遗传(Epigenesis, Genetic);结直肠肿瘤(Colorectal Neoplasms);突变(Mutation)

DOI 10.3389/fimmu.2022.1039631

PMID 36479108

发布时间 2024-09-08

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