Mapping the protein binding site of the (pro)renin receptor using in silico 3D structural analysis.

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作者： Akio,Ebihara ^[1] ; Daiki,Sugihara ^[2] ; Makoto,Matsuyama ^[3] ; Chiharu,Suzuki-Nakagawa ^[4] ; A H M Nurun,Nabi ^[5] ; Tsutomu,Nakagawa ^[6] ; Akira,Nishiyama ^[7] ; Fumiaki,Suzuki ^[8]

作者单位： Faculty of Applied Biological Sciences, Gifu University, Tokai National Higher Education and Research System, 1-1 Yanagido, Gifu, 501-1193, Japan. ebihara.akio.v9@f.gifu-u.ac.jp. ^[1] Center for Highly Advanced Integration of Nano and Life Sciences (G-CHAIN), Gifu University, Tokai National Higher Education and Research System, 1-1 Yanagido, Gifu, 501-1193, Japan. ebihara.akio.v9@f.gifu-u.ac.jp. ^[2] Preemptive Food Research Center (PFRC), Gifu University Institute for Advanced Study, 1-1 Yanagido, Gifu, 501-1193, Japan. ebihara.akio.v9@f.gifu-u.ac.jp. ^[3] Department of Chemical Engineering, Indian Institute of Technology Guwahati, Guwahati, Assam, 781039, India. ebihara.akio.v9@f.gifu-u.ac.jp. ^[4] Graduate School of Natural Science and Technology, Gifu University, Tokai National Higher Education and Research System, 1-1 Yanagido, Gifu, 501-1193, Japan. ^[5] Division of Molecular Genetics, Shigei Medical Research Institute, Okayama, Minami, 701-0202, Japan. ^[6] Faculty of Applied Biological Sciences, Gifu University, Tokai National Higher Education and Research System, 1-1 Yanagido, Gifu, 501-1193, Japan. ^[7] Laboratory of Population Genetics, Department of Biochemistry and Molecular Biology, University of Dhaka, Dhaka, 1000, Bangladesh. ^[8] Department of Pharmacology, Faculty of Medicine, Kagawa University, Miki, Kagawa, 761-0793, Japan. ^[9]

关键词 (Pro)renin receptor AlphaFold2 Intrinsically disordered region Pancreatic ductal adenocarcinoma Wnt/β-catenin signaling

主题词人类(Humans);β连环素(beta Catenin);结合部位(Binding Sites);癌, 胰腺管(Carcinoma, Pancreatic Ductal);胰腺肿瘤(Pancreatic Neoplasms);蛋白质结合(Protein Binding)

DOI 10.1038/s41440-022-01094-w

PMID 36481966

发布时间 2023-12-13

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准确一般字义偏差语意偏离译文作用小提交