Molecular Biomarkers of Disease Outcomes and Mechanisms of Acquired Resistance to First-Line Osimertinib in Advanced EGFR-Mutant Lung Cancers.

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第一作者： Noura J,Choudhury

第一单位： Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York; Department of Medicine, Weill Cornell Medical College, New York, New York.

作者： Noura J,Choudhury ^[1] ; Antonio,Marra ^[2] ; Jane S Y,Sui ^[3] ; Jessica,Flynn ^[4] ; Soo-Ryum,Yang ^[5] ; Christina J,Falcon ^[3] ; Pier,Selenica ^[2] ; Adam J,Schoenfeld ^[1] ; Natasha,Rekhtman ^[5] ; Daniel,Gomez ^[6] ; Michael F,Berger ^[7] ; Marc,Ladanyi ^[7] ; Maria,Arcila ^[5] ; Charles M,Rudin ^[1] ; Gregory J,Riely ^[1] ; Mark G,Kris ^[1] ; Glenn,Heller ^[4] ; Jorge S,Reis-Filho ^[8] ; Helena A,Yu ^[9]

作者单位： Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York; Department of Medicine, Weill Cornell Medical College, New York, New York. ^[1] Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York. ^[2] Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York. ^[3] Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York. ^[4] Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, New York. ^[5] Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, New York. ^[6] Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York; Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, New York; Marie-Josee and Henry R. Kravis Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center, New York, New York. ^[7] Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York; Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, New York. ^[8] Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York; Department of Medicine, Weill Cornell Medical College, New York, New York. Electronic address: yuh@mskcc.org. ^[9]

关键词 EGFR Mechanisms of resistance Osimertinib Targeted therapies Tumor evolution

主题词人类(Humans);癌, 非小细胞肺(Carcinoma, Non-Small-Cell Lung);肺肿瘤(Lung Neoplasms);蛋白激酶抑制剂(Protein Kinase Inhibitors);抗药性, 肿瘤(Drug Resistance, Neoplasm)

DOI 10.1016/j.jtho.2022.11.022

PMID 36494075

发布时间 2024-04-02

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