Cystatin B increases autophagic flux by sustaining proteolytic activity of cathepsin B and fuels glycolysis in pancreatic cancer: CSTB orchestrates autophagy and glycolysis in PDAC.

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作者： Yongsheng,Jiang ^[1] ; Lijie,Han ^[2] ; Meilin,Xue ^[3] ; Ting,Wang ^[1] ; Youwei,Zhu ^[2] ; Cheng,Xiong ^[3] ; Minmin,Shi ^[1] ; Hongzhe,Li ^[2] ; Wangxi,Hai ^[3] ; Yanmiao,Huo ^[4] ; Baiyong,Shen ^[1] ; Lingxi,Jiang ^[2] ; Hao,Chen ^[3]

作者单位： Department of General Surgery, Pancreatic Disease Center, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ^[1] Research Institute of Pancreatic Diseases, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ^[2] State Key Laboratory of Oncogenes and Related Genes, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ^[3] Department of Pathology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ^[4] Department of Nuclear Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ^[5] Department of Biliary-Pancreatic Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, P. R. China. ^[6] Institute of Translational Medicine, Shanghai Jiao Tong University, Shanghai, China. ^[7]

关键词 autophagy biomarker cathepsin B cystatin B cystatin C glycolysis pancreatic ductal adenocarcinoma

主题词人类(Humans);小鼠(Mice);动物(Animals);半胱氨酸蛋白酶抑制物B(Cystatin B);组织蛋白酶B(Cathepsin B);细胞系, 肿瘤(Cell Line, Tumor);癌, 胰腺管(Carcinoma, Pancreatic Ductal);胰腺肿瘤(Pancreatic Neoplasms);自噬(Autophagy)

DOI 10.1002/ctm2.1126

PMID 36495123

发布时间 2023-12-13

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Clinical and translational medicine

2022年12卷12期

e1126页

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Cystatin B increases autophagic flux by sustaining proteolytic activity of cathepsin B and fuels glycolysis in pancreatic cancer: CSTB orchestrates autophagy and glycolysis in PDAC.

Clinical and translational medicine

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Clinical and translational medicine

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Cystatin B increases autophagic flux by sustaining proteolytic activity of cathepsin B and fuels glycolysis in pancreatic cancer: CSTB orchestrates autophagy and glycolysis in PDAC.

Clinical and translational medicine

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Clinical and translational medicine

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