首页> Developmental cell> RNA degradation eliminates developmental transcripts during murine embryonic stem cell differentiation via CAPRIN1-XRN2.

RNA degradation eliminates developmental transcripts during murine embryonic stem cell differentiation via CAPRIN1-XRN2.

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第一作者： Juliane O,Viegas

第一单位： Department of Genetics, The Institute of Life Sciences, The Hebrew University of Jerusalem, Edmond J. Safra Campus, Jerusalem 9190401, Israel.

作者： Juliane O,Viegas ^[1] ; Gajendra Kumar,Azad ^[2] ; Yuan,Lv ^[3] ; Lior,Fishman ^[1] ; Tal,Paltiel ^[1] ; Sundararaghavan,Pattabiraman ^[4] ; Jung Eun,Park ^[5] ; Daniel,Kaganovich ^[6] ; Siu Kwan,Sze ^[7] ; Michal,Rabani ^[1] ; Miguel A,Esteban ^[3] ; Eran,Meshorer ^[8]

作者单位： Department of Genetics, The Institute of Life Sciences, The Hebrew University of Jerusalem, Edmond J. Safra Campus, Jerusalem 9190401, Israel. ^[1] Department of Genetics, The Institute of Life Sciences, The Hebrew University of Jerusalem, Edmond J. Safra Campus, Jerusalem 9190401, Israel; Department of Zoology, Patna University, Patna, Bihar 800005, India. ^[2] Laboratory of Integrative Biology, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China. ^[3] School of Biological Sciences, University of Southampton, Southampton SO171BJ, UK. ^[4] School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore 637551, Singapore. ^[5] School of Biological Sciences, University of Southampton, Southampton SO171BJ, UK; Wren Therapeutics, Cambridge CB21EW, UK. ^[6] School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore 637551, Singapore; Faculty of Applied Health Sciences, Brock University, St. Catharines, ON, Canada. ^[7] The Edmond and Lily Safra Center for Brain Sciences, The Hebrew University of Jerusalem, Edmond J. Safra Campus, Jerusalem 9190401, Israel. Electronic address: eran.meshorer@mail.huji.ac.il. ^[8]

关键词 CAPRIN1 RNA degradation RNA stability XRN2 differentiation embryonic stem cells pluripotency stress granules

医学主题词动物(Animals);小鼠(Mice);细胞周期(Cell Cycle);细胞周期蛋白质类(Cell Cycle Proteins);细胞分化(Cell Differentiation);RNA稳定性(RNA Stability);外切核糖核酸酶类(Exoribonucleases)

DOI 10.1016/j.devcel.2022.11.014

PMID 36495875

发布时间 2023-01-30

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