Comparative Modelling of Organic Anion Transporting Polypeptides: Structural Insights and Comparison of Binding Modes.

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作者： Arun Kumar,Tonduru ^[1] ; Santosh Kumar,Adla ^[1] ; Kristiina M,Huttunen ^[2] ; Thales,Kronenberger ^[1] ; Antti,Poso ^[1]

作者单位： School of Pharmacy, Faculty of Health Sciences, University of Eastern Finland, P.O. Box 1627, 70211 Kuopio, Finland. ^[1] Institute of Organic Chemistry and Biochemistry (IOCB), Czech Academy of Sciences, Flemingovo Namesti 542/2, 160 00 Prague, Czech Republic. ^[2] Department of Internal Medicine VIII, University Hospital Tuebingen, Otfried-Müller-Strasse 14, 72076 Tuebingen, Germany. ^[3] Department of Pharmaceutical and Medicinal Chemistry, Institute of Pharmaceutical Sciences, Eberhard-Karls-Universität, Tuebingen, Auf der Morgenstelle 8, 72076 Tuebingen, Germany. ^[4] Cluster of Excellence iFIT (EXC 2180) "Image-Guided and Functionally Instructed Tumor Therapies", University of Tübingen, 72076 Tuebingen, Germany. ^[5] Tuebingen Center for Academic Drug Discovery & Development (TüCAD2), 72076 Tuebingen, Germany. ^[6]

关键词 Solute-Carrier O (SLCO)homology models molecular dynamics simulations organic anion transporting polypeptides (OATPs)xenobiotic transporters

主题词有机阴离子转运子(Organic Anion Transporters);生物转运(Biological Transport)

DOI 10.3390/molecules27238531

PMID 36500622

发布时间 2022-12-21

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准确一般字义偏差语意偏离译文作用小提交