首页> BMC cancer> Markers associated with genomic instability, immunogenicity and immune therapy responsiveness in Metaplastic carcinoma of the breast: Expression of γH2AX, pRPA2, P53, PD-L1 and tumor infiltrating lymphocytes in 76 cases.

Markers associated with genomic instability, immunogenicity and immune therapy responsiveness in Metaplastic carcinoma of the breast: Expression of γH2AX, pRPA2, P53, PD-L1 and tumor infiltrating lymphocytes in 76 cases.

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第一作者： S,Voutilainen

第一单位： Helsinki University Hospital Comprehensive Cancer Centre, Paciuksenkatu 3, PO BOX 180, 00290, Helsinki, Finland. sari.j.voutilainen@hus.fi.

作者： S,Voutilainen ^[1] ; P,Heikkilä ^[2] ; J,Bartkova ^[3] ; H,Nevanlinna ^[4] ; C,Blomqvist ^[5] ; J,Bartek ^[3] ; J,Mattson ^[5]

作者单位： Helsinki University Hospital Comprehensive Cancer Centre, Paciuksenkatu 3, PO BOX 180, 00290, Helsinki, Finland. sari.j.voutilainen@hus.fi. ^[1] Department of Pathology, University of Helsinki and HUSLAB, Helsinki University Hospital, Helsinki, Finland. ^[2] Danish Cancer Society Research Center, Copenhagen, Denmark.;Division of Genome Biology, Department of Medical Biochemistry and Biophysics, Science for Life Laboratory, Karolinska Institute, Stockholm, Sweden. ^[3] Department of Obstetrics and Gynecology, University of Helsinki, Helsinki University Hospital, Helsinki, Finland. ^[4] Helsinki University Hospital Comprehensive Cancer Centre, Paciuksenkatu 3, PO BOX 180, 00290, Helsinki, Finland. ^[5]

关键词 Metaplastic breast cancer PD-L1 RPA2 TILs p53 γH2AX

医学主题词人类(Humans);淋巴细胞, 肿瘤浸润(Lymphocytes, Tumor-Infiltrating);肿瘤抑制蛋白质p53(Tumor Suppressor Protein p53);预后(Prognosis);癌, 鳞状细胞(Carcinoma, Squamous Cell)

DOI 10.1186/s12885-022-10408-7

PMID 36503417

发布时间 2022-12-21

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