Intracellular osteopontin protects from autoimmunity-driven lymphoma development inhibiting TLR9-MYD88-STAT3 signaling.

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作者： Celeste,Rizzello ^[1] ; Valeria,Cancila ^[2] ; Sabina,Sangaletti ^[1] ; Laura,Botti ^[1] ; Chiara,Ratti ^[1] ; Matteo,Milani ^[1] ; Matteo,Dugo ^[3] ; Francesco,Bertoni ^[4] ; Claudio,Tripodo ^[5] ; Claudia,Chiodoni ^[6] ; Mario P,Colombo ^[2]

作者单位： Molecular Immunology Unit, Department of Research, Fondazione IRCCS Istituto Nazionale Tumori, Via Venezian 1, 20133, Milan, Italy. ^[1] Tumor Immunology Unit, Department of Health Science, University of Palermo School of Medicine, Palermo, Italy. ^[2] Platform of Integrated Biology, Department of Applied Research and Technology Development, Fondazione IRCCS Istituto Nazionale Tumori, Via Venezian 1, 20133, Milan, Italy. ^[3] Department of Medical Oncology, IRCCS Ospedale San Raffaele, Via Olgettina 60, 20132, Milan, Italy. ^[4] Institute of Oncology Research, Faculty of Biomedical Sciences, USI, Via F. Chiesa 5, 6500, Bellinzona, Switzerland. ^[5] Oncology Institute of Southern Switzerland, Ente Ospedialiero Cantonale, Via A. Gallino 12, 6500, Bellinzona, Switzerland. ^[6] FIRC Institute of Molecular Oncology (IFOM), Milan, Italy. ^[7] Molecular Immunology Unit, Department of Research, Fondazione IRCCS Istituto Nazionale Tumori, Via Venezian 1, 20133, Milan, Italy. claudia.chiodoni@istitutotumori.mi.it. ^[8] Molecular Immunology Unit, Department of Research, Fondazione IRCCS Istituto Nazionale Tumori, Via Venezian 1, 20133, Milan, Italy. mariopaolo.colombo@istitutotumori.mi.it. ^[9]

关键词 Autoimmunity Diffuse large B cell lymphoma Osteopontin