Single and repeated dose (28 days) intravenous toxicity assessment of bartogenic acid (an active pentacyclic triterpenoid) isolated from <i>Barringtonia racemosa</i> (L.) fruits in mice.
第一作者:
Vishal Kumar,Dubey
第一单位:
Dabur Research Foundation, 22, Site IV, Sahibabad, Ghaziabad 201010, Uttar Pradesh, India.;Amity Institute of Pharmacy, Amity University Uttar Pradesh, Sector-125, Noida 201313, Uttar Pradesh, India.
作者:
关键词
AAALAC, Association For Assessment And Accreditation Of Laboratory Animal CareALP, Alkaline PhosphataseALT, Alanine AminotransferaseAST, Aspartate AminotransferaseAcuteBA, Bartogenic AcidBUN, Blood Urea NitrogenBarringtonia racemosaBartogenic acidFDA, Food And Drug AdministrationGLP, Good Laboratory PracticeH&E, Hematoxylin–EosinHCT, HematocritLC/MS, Liquid chromatography–mass spectrometryMCH, Mean Corpuscular HemoglobinMCHC, Mean Corpuscular Hemoglobin ConcentrationMCV, Mean Corpuscular VolumeMiceNMR, Nuclear Magnetic ResonanceNOAELNOAEL, No Observed Adverse Effect LevelOA, Oleanolic AcidOECD, Organization For Economic Co-Operation And DevelopmentRBC, Red Blood Cells CountRDW-CV, Red Cell Distribution Width - Coefficient Of VariationSEM, Standard Error Of The MeanTLC, Total Leukocyte CountToxicityUA, Ursolic AcidUHPLC, Ultra High Performance Liquid ChromatographyVLDL, Very Low Density Lipoproteinb.wt., Body Weight
DOI
10.1016/j.crtox.2021.10.004
PMID
36504921
发布时间
2022-12-20
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Current research in toxicology
2022年3卷
100057页
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