Metformin inhibits oral squamous cell carcinoma progression through regulating RNA alternative splicing.

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作者： Minmin,Ji ^[1] ; Yuesheng,Lv ^[2] ; Chaoqun,Chen ^[2] ; Dingya,Xing ^[3] ; Chao,Zhou ^[4] ; Jinyao,Zhao ^[2] ; Yangfan,Qi ^[2] ; Jinrui,Zhang ^[2] ; Yang,Wang ^[2] ; Xiang,Ma ^[5] ; Wei,Xu ^[6] ; Wenjing,Zhang ^[7] ; Xiaojie,Li ^[8]

作者单位： Institute of Cancer Stem Cell, Dalian Medical University, Dalian, China; Department of Prosthodontics, College of Stomatology, Dalian Medical University, Dalian, China; Department of Stomatology, Shandong Second Provincial Hospital, Shandong University, Jinan, China. ^[1] Institute of Cancer Stem Cell, Dalian Medical University, Dalian, China. ^[2] Institute of Cancer Stem Cell, Dalian Medical University, Dalian, China; Department of Prosthodontics, College of Stomatology, Dalian Medical University, Dalian, China. ^[3] Department of Otolaryngology-Head and Neck Surgery, Shandong Provincial ENT Hospital, Shandong University, Jinan, China; Shandong Institute of Otorhinolaryngology, Jinan, China. ^[4] Department of Ophthalmology, The First Affiliated Hospital of Dalian Medical University, Dalian, China. ^[5] Department of Otolaryngology-Head and Neck Surgery, Shandong Provincial ENT Hospital, Shandong University, Jinan, China; Shandong Institute of Otorhinolaryngology, Jinan, China. Electronic address: xuwhns@126.com. ^[6] Institute of Cancer Stem Cell, Dalian Medical University, Dalian, China. Electronic address: zhangwj@dmu.edu.cn. ^[7] Department of Prosthodontics, College of Stomatology, Dalian Medical University, Dalian, China. Electronic address: xiaojieli0504@dmu.edu.cn. ^[8]

关键词 Alternative splicing Metformin NUBP2 OSCC

主题词人类(Humans);癌, 鳞状细胞(Carcinoma, Squamous Cell);RNA(RNA);口腔肿瘤(Mouth Neoplasms);选择性剪接(Alternative Splicing);二甲双胍(Metformin);细胞增殖(Cell Proliferation);头颈部肿瘤(Head and Neck Neoplasms);细胞系, 肿瘤(Cell Line, Tumor);细胞运动(Cell Movement);基因表达调控, 肿瘤(Gene Expression Regulation, Neoplastic)

DOI 10.1016/j.lfs.2022.121274

PMID 36509195

发布时间 2023-02-02

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Metformin inhibits oral squamous cell carcinoma progression through regulating RNA alternative splicing.

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Metformin inhibits oral squamous cell carcinoma progression through regulating RNA alternative splicing.

Life sciences

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Life sciences

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