Cannabidiol-induced transcriptomic changes and cellular senescence in human Sertoli cells.

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作者： Yuxi,Li ^[1] ; Xilin,Li ^[2] ; Patrick,Cournoyer ^[3] ; Supratim,Choudhuri ^[4] ; Xiaozhong,Yu ^[5] ; Lei,Guo ^[1] ; Si,Chen ^[1]

作者单位： Division of Biochemical Toxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 72079, USA. ^[1] Division of Genetic and Molecular Toxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 72079, USA. ^[2] Office of the Commissioner, Silver Spring, MD 20993, USA. ^[3] Office of Food Additive Safety, Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, College Park, MD 20740, USA. ^[4] College of Nursing, University of New Mexico, Albuquerque, NM 87131, USA. ^[5]

关键词 DNA repair DNA replication cannabidiol cell cycle cellular senescence mRNA sequencing male reproductive toxicity primary human Sertoli cells

主题词动物(Animals);人类(Humans);男(雄)性(Male);大麻二酚(Cannabidiol);RNA, 信使(RNA, Messenger);塞尔托利细胞(Sertoli Cells)

DOI 10.1093/toxsci/kfac131

PMID 36519830

发布时间 2023-04-25

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