首页> Immunity> Prolonged hypernutrition impairs TREM2-dependent efferocytosis to license chronic liver inflammation and NASH development.

Prolonged hypernutrition impairs TREM2-dependent efferocytosis to license chronic liver inflammation and NASH development.

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第一作者： Xiaochen,Wang

第一单位： Department of Immunology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

作者： Xiaochen,Wang ^[1] ; Qifeng,He ^[2] ; Chuanli,Zhou ^[1] ; Yueyuan,Xu ^[3] ; Danhui,Liu ^[1] ; Naoto,Fujiwara ^[4] ; Naoto,Kubota ^[4] ; Arielle,Click ^[1] ; Polly,Henderson ^[1] ; Janiece,Vancil ^[1] ; Cesia Ammi,Marquez ^[4] ; Ganesh,Gunasekaran ^[5] ; Myron E,Schwartz ^[5] ; Parissa,Tabrizian ^[5] ; Umut,Sarpel ^[5] ; Maria Isabel,Fiel ^[6] ; Yarui,Diao ^[3] ; Beicheng,Sun ^[7] ; Yujin,Hoshida ^[4] ; Shuang,Liang ^[8] ; Zhenyu,Zhong ^[9]

作者单位： Department of Immunology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. ^[1] Department of General Surgery, Nanjing First Hospital, The Affiliated Nanjing Hospital of Nanjing Medical University, Nanjing 210006, Jiangsu, China. ^[2] Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA; Duke Regeneration Center, Center for Advanced Genomic Technologies, Duke University Medical Center, Durham, NC 27710, USA. ^[3] Division of Digestive and Liver Diseases, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. ^[4] Department of Surgery, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. ^[5] Department of Pathology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. ^[6] Department of Hepatobiliary Surgery, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, Jiangsu, China. ^[7] Department of Immunology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address: shuang.liang@utsouthwestern.edu. ^[8] Department of Immunology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address: zhenyu.zhong@utsouthwestern.edu. ^[9]

关键词 TREM2 chronic inflammation efferocytosis nonalcoholic steatohepatitis proinflammatory cytokines

医学主题词人类(Humans);营养过剩(Overnutrition);肝(Liver);炎症(Inflammation);肥胖症(Obesity);膜糖蛋白类(Membrane Glycoproteins);受体, 免疫(Receptors, Immunologic)

DOI 10.1016/j.immuni.2022.11.013

PMID 36521495

发布时间 2024-01-11

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