Proteoid biodynamers for safe mRNA transfection via pH-responsive nanorods enabling endosomal escape.

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作者： Sangeun,Lee ^[1] ; Sarah,Nasr ^[2] ; Sari,Rasheed ^[3] ; Yun,Liu ^[4] ; Olga,Hartwig ^[5] ; Cansu,Kaya ^[5] ; Annette,Boese ^[4] ; Marcus,Koch ^[6] ; Jennifer,Herrmann ^[3] ; Rolf,Müller ^[7] ; Brigitta,Loretz ^[4] ; Eric,Buhler ^[8] ; Anna K H,Hirsch ^[9] ; Claus-Michael,Lehr ^[10]

作者单位： Helmholtz Institute for Pharmaceutical Research Saarland (HIPS) - Helmholtz Centre for Infection Research (HZI), Campus E 8.1, 66123 Saarbrücken, Germany; Department of Pharmacy, Saarland University, 66123 Saarbrücken, Germany. Electronic address: sangeun.lee@uni-saarland.de. ^[1] Helmholtz Institute for Pharmaceutical Research Saarland (HIPS) - Helmholtz Centre for Infection Research (HZI), Campus E 8.1, 66123 Saarbrücken, Germany; Department of Pharmacy, Saarland University, 66123 Saarbrücken, Germany; Department of Pharmaceutics, Faculty of Pharmacy, Alexandria University, Egypt. ^[2] Helmholtz Institute for Pharmaceutical Research Saarland (HIPS) - Helmholtz Centre for Infection Research (HZI), Campus E 8.1, 66123 Saarbrücken, Germany; German Centre for Infection Research (DZIF), Braunschweig, Germany. ^[3] Helmholtz Institute for Pharmaceutical Research Saarland (HIPS) - Helmholtz Centre for Infection Research (HZI), Campus E 8.1, 66123 Saarbrücken, Germany. ^[4] Helmholtz Institute for Pharmaceutical Research Saarland (HIPS) - Helmholtz Centre for Infection Research (HZI), Campus E 8.1, 66123 Saarbrücken, Germany; Department of Pharmacy, Saarland University, 66123 Saarbrücken, Germany. ^[5] INM - Leibniz Institute for New Materials, Campus D2 2, 66123 Saarbrücken, Germany. ^[6] Helmholtz Institute for Pharmaceutical Research Saarland (HIPS) - Helmholtz Centre for Infection Research (HZI), Campus E 8.1, 66123 Saarbrücken, Germany; Department of Pharmacy, Saarland University, 66123 Saarbrücken, Germany; German Centre for Infection Research (DZIF), Braunschweig, Germany; Helmholtz International Lab - Helmholtz Centre for Infection Research (HZI), Campus E 8.1, 66123 Saarbrücken, Germany. ^[7] Laboratoire Matière et Systèmes Complexes (MSC), UMR CNRS 7057, Université Paris Cité, Bâtiment Condorcet, 75205 Paris Cedex 13, France. ^[8] Helmholtz Institute for Pharmaceutical Research Saarland (HIPS) - Helmholtz Centre for Infection Research (HZI), Campus E 8.1, 66123 Saarbrücken, Germany; Department of Pharmacy, Saarland University, 66123 Saarbrücken, Germany; Helmholtz International Lab - Helmholtz Centre for Infection Research (HZI), Campus E 8.1, 66123 Saarbrücken, Germany. Electronic address: anna.hirsch@helmholtz-hips.de. ^[9] Helmholtz Institute for Pharmaceutical Research Saarland (HIPS) - Helmholtz Centre for Infection Research (HZI), Campus E 8.1, 66123 Saarbrücken, Germany; Department of Pharmacy, Saarland University, 66123 Saarbrücken, Germany. Electronic address: claus-michael.lehr@helmholtz-hips.de. ^[10]

关键词 Biopolymer Gene delivery Nanorod Polymeric vector Stimuli-responsive Structure analysis mRNA delivery

主题词人类(Humans);RNA, 信使(RNA, Messenger);转染(Transfection);内颗粒(Endosomes);氢离子浓度(Hydrogen-Ion Concentration);脂类(Lipids)

DOI 10.1016/j.jconrel.2022.12.018

PMID 36521693

发布时间 2023-02-13

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