IL-1β promotes osteoclastogenesis by increasing the expression of IGF2 and chemokines in non-osteoclastic cells.

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作者： Yuto,Otsuka ^[1] ; Takao,Kondo ^[1] ; Hiromasa,Aoki ^[1] ; Yoh,Goto ^[2] ; Yohei,Kawaguchi ^[3] ; Yuko,Waguri-Nagaya ^[4] ; Ken,Miyazawa ^[2] ; Shigemi,Goto ^[2] ; Mineyoshi,Aoyama ^[5]

作者单位： Department of Pathobiology, Nagoya City University Graduate School of Pharmaceutical Sciences, 3-1 Tanabe-dori, Mizuho-ku, Nagoya 467-8603, Japan. ^[1] Department of Orthodontics, School of Dentistry, Aichi-Gakuin University, 1-100 Kusumoto-cho, Chikusa-ku, Nagoya 464-8650, Japan. ^[2] Department of Glial Cell Biology, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya 467-8601, Japan; Department of Orthopaedic Surgery, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya 467-8601, Japan. ^[3] Department of Orthopaedic Surgery, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya 467-8601, Japan. ^[4] Department of Pathobiology, Nagoya City University Graduate School of Pharmaceutical Sciences, 3-1 Tanabe-dori, Mizuho-ku, Nagoya 467-8603, Japan. Electronic address: aomine@phar.nagoya-cu.ac.jp. ^[5]

关键词 Chemokine IGF2 IL-1β Microenvironment Osteoclast