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Hyaluronan driven by epithelial aPKC deficiency remodels the microenvironment and creates a vulnerability in mesenchymal colorectal cancer.

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第一作者： Anxo,Martinez-Ordoñez

第一单位： Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, 1300 York Avenue, New York, NY 10065, USA.

作者： Anxo,Martinez-Ordoñez ^[1] ; Angeles,Duran ^[1] ; Marc,Ruiz-Martinez ^[1] ; Tania,Cid-Diaz ^[1] ; Xiao,Zhang ^[1] ; Qixiu,Han ^[1] ; Hiroto,Kinoshita ^[1] ; Yu,Muta ^[1] ; Juan F,Linares ^[1] ; Hiroaki,Kasashima ^[2] ; Yuki,Nakanishi ^[3] ; Mohamed,Omar ^[1] ; Sadaaki,Nishimura ^[1] ; Leandro,Avila ^[1] ; Masakazu,Yashiro ^[2] ; Kiyoshi,Maeda ^[2] ; Tania,Pannellini ^[1] ; Alessio,Pigazzi ^[4] ; Giorgio,Inghirami ^[1] ; Luigi,Marchionni ^[1] ; Darren,Sigal ^[5] ; Maria T,Diaz-Meco ^[6] ; Jorge,Moscat ^[7]

作者单位： Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, 1300 York Avenue, New York, NY 10065, USA. ^[1] Department of Gastroenterological Surgery, Osaka Metropolitan University Graduate School of Medicine, 1-4-3 Asahimachi, Abeno-ku, Osaka City 545-8585, Japan. ^[2] Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Kyoto, Japan. ^[3] Department of Surgery, Weill Cornell Medicine, 1300 York Avenue, New York, NY 10065, USA. ^[4] Division of Hematology-Oncology, Scripps Clinic, La Jolla, CA 92037, USA. ^[5] Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, 1300 York Avenue, New York, NY 10065, USA. Electronic address: mtd4001@med.cornell.edu. ^[6] Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, 1300 York Avenue, New York, NY 10065, USA. Electronic address: jom4010@med.cornell.edu. ^[7]

关键词 aPKC colorectal cancer hyaluronan immune checkpoint therapy immunosuppression inflammation liver metastasis mesenchymal stroma tumor microenvironment

医学主题词人类(Humans);CD8阳性T淋巴细胞(CD8-Positive T-Lymphocytes);结直肠肿瘤(Colorectal Neoplasms);透明质酸(Hyaluronic Acid);免疫疗法(Immunotherapy);肉瘤(Sarcoma);肿瘤微环境(Tumor Microenvironment)

DOI 10.1016/j.ccell.2022.11.016

PMID 36525970

发布时间 2024-02-14

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准确一般字义偏差语意偏离译文作用小提交