Ketogenic diet restores hormonal, apoptotic/proliferative balance and enhances the effect of metformin on a letrozole-induced polycystic ovary model in rats.

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第一作者： Al-Shaimaa F,Ahmed

第一单位： Department of Pharmacology and Toxicology, Faculty of Pharmacy, Minia University, Minia, Egypt. Electronic address: Shaimaa_faissal@minia.edu.eg.

作者： Al-Shaimaa F,Ahmed ^[1] ; Sara S,Sharkawi ^[2] ; Sara S,AbdelHameed ^[2] ; Asmaa M,Bayoumi ^[3] ; Rabab S,Moussa ^[4] ; Nabil A,Alhakamy ^[5] ; Hadeel,Al Sadoun ^[6] ; Rasha A,Mansouri ^[7] ; Mohamed A,El-Moselhy ^[8] ; Mahmoud,El-Daly ^[2] ; Aliaa F,Anter ^[2]

作者单位： Department of Pharmacology and Toxicology, Faculty of Pharmacy, Minia University, Minia, Egypt. Electronic address: Shaimaa_faissal@minia.edu.eg. ^[1] Department of Pharmacology and Toxicology, Faculty of Pharmacy, Minia University, Minia, Egypt. ^[2] Department of Biochemistry, Faculty of Pharmacy, Minia University, Minia, Egypt. ^[3] Department of Pathology, Faculty of Medicine, Minia University, Minia, Egypt. ^[4] Department of Pharmaceutics, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia; Center of Excellence for Drug Research and Pharmaceutical Industries, King Abdulaziz University, Jeddah 21589, Saudi Arabia; Mohamed Saeed Tamer Chair for Pharmaceutical Industries, King Abdulaziz University, Jeddah 21589, Saudi Arabia. ^[5] Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah 21589, Saudi Arabia. ^[6] Department of Biochemistry, Faculty of Sciences, King Abdulaziz University, Jeddah 21589, Saudi Arabia. ^[7] Clinical Pharmacy and Pharmacology Department, Ibn Sina National College for Medical Studies, Jeddah 21589, Saudi Arabia. ^[8]

关键词 Caspase-3 Cystic follicles Letrozole PCNA TGF

主题词人类(Humans);大鼠(Rats);女(雌)性(Female);动物(Animals);二甲双胍(Metformin);多囊卵巢综合征(Polycystic Ovary Syndrome)

DOI 10.1016/j.lfs.2022.121285

PMID 36526050

发布时间 2023-06-04

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Ketogenic diet restores hormonal, apoptotic/proliferative balance and enhances the effect of metformin on a letrozole-induced polycystic ovary model in rats.

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Ketogenic diet restores hormonal, apoptotic/proliferative balance and enhances the effect of metformin on a letrozole-induced polycystic ovary model in rats.

Life sciences

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Life sciences

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