Impact of Sotorasib on the Pharmacokinetics and Pharmacodynamics of Metformin, a MATE1/2K Substrate, in Healthy Subjects.

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第一作者： Irene,Vuu

第一单位： Clinical Pharmacology Modeling and Simulation, Amgen, Inc., 1 Amgen Center Dr., Thousand Oaks, CA, 91320, USA. ivuu@amgen.com.

作者： Irene,Vuu ^[1] ; Jan,Wahlstrom ^[2] ; Brett E,Houk ^[3]

作者单位： Clinical Pharmacology Modeling and Simulation, Amgen, Inc., 1 Amgen Center Dr., Thousand Oaks, CA, 91320, USA. ivuu@amgen.com. ^[1] Pharmacokinetics and Drug Metabolism, Amgen, Inc., San Francisco, CA, USA. ^[2] Clinical Pharmacology Modeling and Simulation, Amgen, Inc., 1 Amgen Center Dr., Thousand Oaks, CA, 91320, USA. ^[3]

主题词人类(Humans);二甲双胍(Metformin);癌, 非小细胞肺(Carcinoma, Non-Small-Cell Lung);药物相互作用(Drug Interactions);曲线下面积(Area Under Curve);肺肿瘤(Lung Neoplasms)

DOI 10.1007/s40262-022-01192-5

PMID 36529835

发布时间 2023-05-11

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准确一般字义偏差语意偏离译文作用小提交