Hierarchical Macro-Mesoporous Silica Monolithic Tablets as a Novel Dose-Structure-Dependent Delivery System for the Release of Confined Dexketoprofen.

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第一作者： Marta,Kozakiewicz-Latała

第一单位： Department of Drug Forms Technology, Faculty of Pharmacy, Wroclaw Medical University, Borowska 211, Wroclaw50-556, Poland.

作者： Marta,Kozakiewicz-Latała ^[1] ; Dominik,Marciniak ^[1] ; Karolina,Krajewska ^[1] ; Adrianna,Złocińska ^[2] ; Krystian,Prusik ^[3] ; Bożena,Karolewicz ^[1] ; Karol P,Nartowski ^[1] ; Wojciech,Pudło ^[4]

作者单位： Department of Drug Forms Technology, Faculty of Pharmacy, Wroclaw Medical University, Borowska 211, Wroclaw50-556, Poland. ^[1] Laboratory of Elemental Analysis Structural Research, Wroclaw Medical University, Borowska 211, Wroclaw50-556, Poland. ^[2] Institute of Materials Engineering, University of Silesia in Katowice, 75 Pulku Piechoty 1A, Chorzow40-007, Poland.;Silesian Center for Education and Interdisciplinary Research, University of Silesia in Katowice, 75 Pulku Piechoty 1A, Chorzow40-007, Poland. ^[3] Department of Chemical Engineering and Process Design, Silesian University of Technology, Gliwice44-100, Poland. ^[4]

关键词 controlled and adjustable release of dexketoprofen dexketoprofen crystallization in macroporous structures hierarchical porous drug carriers macropore-favored crystallization silica monolithic tablets