Chronic acidosis rewires cancer cell metabolism through PPARα signaling.

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作者： Michala G,Rolver ^[1] ; Lya K K,Holland ^[2] ; Muthulakshmi,Ponniah ^[1] ; Nanditha S,Prasad ^[1] ; Jiayi,Yao ^[3] ; Julie,Schnipper ^[4] ; Signe,Kramer ^[1] ; Line,Elingaard-Larsen ^[5] ; Elena,Pedraz-Cuesta ^[1] ; Bin,Liu ^[2] ; Luis A,Pardo ^[6] ; Kenji,Maeda ^[2] ; Albin,Sandelin ^[3] ; Stine Falsig,Pedersen ^[1]

作者单位： Section for Cell Biology and Physiology, Department of Biology, University of Copenhagen, Copenhagen, Denmark. ^[1] Cell Death and Metabolism, Center for Autophagy, Recycling and Disease, Danish Cancer Society Research Center, Copenhagen, Denmark. ^[2] The Bioinformatics Center, Department of Biology, University of Copenhagen, Copenhagen, Denmark.;Biotech Research and Innovation Center, University of Copenhagen, Copenhagen, Denmark. ^[3] Laboratory of Cellular and Molecular Physiology, University of Picardie Jules Verne, Amiens, France. ^[4] Department of Clinical Research, Steno Diabetes Center Copenhagen, Herlev, Denmark. ^[5] Oncophysiology Group, Max-Planck-Institute for Multidisciplinary Sciences, Göttingen, Germany. ^[6]

关键词 PPARα acidic microenvironment cancer metabolism fatty acid metabolism β-oxidation