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Safety and activity of anti-CD14 antibody IC14 (atibuclimab) in ALS: Experience with expanded access protocol.

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第一作者： Dario,Gelevski

第一单位： Department of Neurology, Sean M. Healey and AMG Center for ALS and the Neurological Clinical Research Institute, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States.

作者： Dario,Gelevski ^[1] ; Grace,Addy ^[1] ; Margot,Rohrer ^[1] ; Caroline,Cohen ^[1] ; Aimee,Roderick ^[1] ; Allison,Winter ^[1] ; Judith,Carey ^[1] ; Jennifer,Scalia ^[1] ; Megan,Yerton ^[1] ; Harli,Weber ^[1] ; Michael,Doyle ^[1] ; Neil,Parikh ^[1] ; Geli,Kane ^[1] ; Amy,Ellrodt ^[1] ; Katherine,Burke ^[1] ; Derek,D'Agostino ^[1] ; Ervin,Sinani ^[2] ; Hong,Yu ^[1] ; Alexander,Sherman ^[1] ; Jan,Agosti ^[2] ; Garry,Redlich ^[2] ; Patrick,Charmley ^[2] ; David,Crowe ^[2] ; Mark,Appleby ^[2] ; Brian,Ziegelaar ^[2] ; Katherine,Hanus ^[3] ; Zhenhua,Li ^[3] ; Suma,Babu ^[1] ; Katharine,Nicholson ^[1] ; Sarah,Luppino ^[1] ; James,Berry ^[1] ; Clare,Baecher-Allan ^[3] ; Sabrina,Paganoni ^[4] ; Merit,Cudkowicz ^[1]

作者单位： Department of Neurology, Sean M. Healey and AMG Center for ALS and the Neurological Clinical Research Institute, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States. ^[1] Implicit Bioscience, Ltd, Brisbane, Australia. ^[2] Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States. ^[3] Department of Neurology, Sean M. Healey and AMG Center for ALS and the Neurological Clinical Research Institute, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States.;Department of Physical Medicine and Rehabilitation, Spaulding Rehabilitation Hospital, Harvard Medical School, Boston, Massachusetts, United States. ^[4]

关键词 IC14 amyotrophic lateral sclerosis expanded access motor neuron disease regulatory T cells

医学主题词美国(United States);人类(Humans);肌萎缩侧索硬化(Amyotrophic Lateral Sclerosis);抗体, 单克隆(Antibodies, Monoclonal);疾病恶化(Disease Progression)

DOI 10.1002/mus.27775

PMID 36533976

发布时间 2023-04-21

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