Pazopanib alleviates neuroinflammation and protects dopaminergic neurons in LPS-stimulated mouse model by inhibiting MEK4-JNK-AP-1 pathway.

导出 OA

翻译打印收藏纠错

第一作者： Hong-Yang,Sun

第一单位： Laboratory of Molecular Neuropathology, Jiangsu Key Laboratory of Neuropsychiatric Diseases and College of Pharmaceutical Sciences, Soochow University, Suzhou, 215123, China.

作者： Hong-Yang,Sun ^[1] ; Jin,Wu ^[1] ; Rui,Wang ^[1] ; Shun,Zhang ^[1] ; Hao,Xu ^[1] ; Еlena,Kaznacheyeva ^[2] ; Xiao-Jun,Lu ^[3] ; Hai-Gang,Ren ^[1] ; Guang-Hui,Wang ^[4]

作者单位： Laboratory of Molecular Neuropathology, Jiangsu Key Laboratory of Neuropsychiatric Diseases and College of Pharmaceutical Sciences, Soochow University, Suzhou, 215123, China. ^[1] Institute of Cytology of Russian Academy of Sciences, Saint-Petersburg, 194064, Russia. ^[2] Department of Neurosurgery, the First People's Hospital of Taicang, Taicang Affiliated Hospital of Soochow University, Suzhou, 215400, China. ^[3] Laboratory of Molecular Neuropathology, Jiangsu Key Laboratory of Neuropsychiatric Diseases and College of Pharmaceutical Sciences, Soochow University, Suzhou, 215123, China. wanggh@suda.edu.cn. ^[4] Center of Translational Medicine, the First People's Hospital of Taicang, Taicang Affiliated Hospital of Soochow University, Suzhou, 215400, China. wanggh@suda.edu.cn. ^[5]

关键词 MEK4-JNK-AP-1 pathway Parkinson’s disease drug repositioning neuroinflammation pazopanib