Targeted Phagocytosis Induction for Cancer Immunotherapy via Bispecific MerTK-Engaging Antibodies.

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作者： Stefania C,Carrara ^[1] ; Jan P,Bogen ^[2] ; David,Fiebig ^[1] ; Julius,Grzeschik ^[2] ; Björn,Hock ^[1] ; Harald,Kolmar ^[2]

作者单位： Institute for Organic Chemistry and Biochemistry, Technical University of Darmstadt, Alarich-Weiss-Strasse 4, D-64287 Darmstadt, Germany. ^[1] Ferring Darmstadt Laboratories, Alarich-Weiss-Strasse 4, D-64287 Darmstadt, Germany. ^[2] Ferring Biologics Innovation Centre, Biopôle, CH-1066 Epalinges, Switzerland. ^[3] Aerium Therapeutics, Biopôle, CH-1066 Epalinges, Switzerland. ^[4] Centre for Synthetic Biology, Technical University of Darmstadt, Alarich-Weiss-Strasse 4, D-64287 Darmstadt, Germany. ^[5]

关键词 BiME EGFR MerTK bispecific antibody macrophages targeted phagocytosis

主题词人类(Humans);抗体, 双特异性(Antibodies, Bispecific);吞噬作用(Phagocytosis);免疫疗法(Immunotherapy);肿瘤(Neoplasms)

DOI 10.3390/ijms232415673

PMID 36555321

发布时间 2022-12-26

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