Natural Product 2-Oxokolavenol Is a Novel FXR Agonist.

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作者： Fusheng,Guo ^[1] ; Yihui,Gao ^[2] ; Xiaobao,Li ^[3] ; Xiaoguang,Lei ^[1]

作者单位： Beijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, Department of Chemical Biology, College of Chemistry and Molecular Engineering, Synthetic and Functional Biomolecules Center, Peking University, Beijing 100871, China.;Peking-Tsinghua Center for Life Science, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing 100871, China. ^[1] Beijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, Department of Chemical Biology, College of Chemistry and Molecular Engineering, Synthetic and Functional Biomolecules Center, Peking University, Beijing 100871, China. ^[2] Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education & Key Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158, China. ^[3]

关键词 2-oxokolavenol FXR high-throughput screening mode of action natural product

主题词人类(Humans);醋氨酚(Acetaminophen);肝疾病(Liver Diseases);受体, 胞质和核(Receptors, Cytoplasmic and Nuclear);肝(Liver)

DOI 10.3390/molecules27248968

PMID 36558100

发布时间 2024-09-09

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