Doxorubicin-Induced Platelet Activation and Clearance Relieved by Salvianolic Acid Compound: Novel Mechanism and Potential Therapy for Chemotherapy-Associated Thrombosis and Thrombocytopenia.

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作者： Wenjing,Ma ^[1] ; Zackary,Rousseau ^[1] ; Sladjana,Slavkovic ^[1] ; Chuanbin,Shen ^[2] ; George M,Yousef ^[3] ; Heyu,Ni ^[4]

作者单位： Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5S 1A1, Canada.;Department of Laboratory Medicine, LKSKI-Keenan Research Centre for Biomedical Science, St. Michael's Hospital, Toronto Platelet Immunobiology Group, Toronto, ON M5B 1W8, Canada. ^[1] Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5S 1A1, Canada.;Department of Laboratory Medicine, LKSKI-Keenan Research Centre for Biomedical Science, St. Michael's Hospital, Toronto Platelet Immunobiology Group, Toronto, ON M5B 1W8, Canada.;School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China. ^[2] Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5S 1A1, Canada.;Department of Laboratory Medicine, LKSKI-Keenan Research Centre for Biomedical Science, St. Michael's Hospital, Toronto Platelet Immunobiology Group, Toronto, ON M5B 1W8, Canada.;Department of Medicine, University of Toronto, Toronto, ON M5S 1A1, Canada. ^[3] Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5S 1A1, Canada.;Department of Laboratory Medicine, LKSKI-Keenan Research Centre for Biomedical Science, St. Michael's Hospital, Toronto Platelet Immunobiology Group, Toronto, ON M5B 1W8, Canada.;Department of Medicine, University of Toronto, Toronto, ON M5S 1A1, Canada.;Canadian Blood Services Centre for Innovation, Toronto, ON M5G 2M1, Canada.;Department of Physiology, University of Toronto, Toronto, ON M5S 1A1, Canada. ^[4]

关键词 cancer-platelet crosstalk doxorubicin platelet activation platelet clearance salvianolic acid C tyrosine phosphorylation

DOI 10.3390/ph15121444

PMID 36558895

发布时间 2024-09-09

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