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In Vitro Diagnostic Assay to Detect SARS-CoV-2-Neutralizing Antibody in Patient Sera Using Engineered ACE-2 Mini-Protein.

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第一作者： Bruna Andersen,Pereira de Jesus

第一单位： Biochemistry Laboratory, Center of Agroveterinary Sciences, State University of Santa Catarina, Lages 88520-000, Brazil.

作者： Bruna Andersen,Pereira de Jesus ^[1] ; Anderson Albino,Gomes ^[1] ; Alex E,Clark ^[2] ; Tayse Andrade,Rodrigues ^[3] ; Melissa,Ledgerwood-Lee ^[2] ; Westley,Van Zant ^[2] ; Howard,Brickner ^[2] ; Meiqiao,Wang ^[4] ; David L,Blum ^[4] ; Maria B,Cassera ^[5] ; Aaron F,Carlin ^[6] ; Eliah S,Aronoff-Spencer ^[2] ; Gustavo Felippe,da Silva ^[1] ; Maria de Lourdes Borba,Magalhães ^[1] ; Partha,Ray ^[2]

作者单位： Biochemistry Laboratory, Center of Agroveterinary Sciences, State University of Santa Catarina, Lages 88520-000, Brazil. ^[1] Department of Medicine, Division of Infectious Diseases and Global Public Health, University of California, San Diego, CA 92093, USA. ^[2] Research and Development Department, Bioclin®, Belo Horizonte 31565-130, Brazil. ^[3] Bioexpression and Fermentation Facility, University of Georgia, Athens, GA 30602, USA. ^[4] Department of Biochemistry and Molecular Biology and Center for Tropical and Emerging Global Diseases (CTEGD), University of Georgia, Athens, GA 30602, USA. ^[5] Department of Medicine, Division of Infectious Diseases and Global Public Health, University of California, San Diego, CA 92093, USA.;Department of Pathology, University of California, San Diego, CA 92093, USA. ^[6]

关键词 ACE2 SARS-CoV-2 engineered mini-protein in vitro diagnostics neutralizing antibodies spike protein

医学主题词人类(Humans);抗体, 病毒(Antibodies, Viral);抗体, 中和(Antibodies, Neutralizing)

DOI 10.3390/v14122823

PMID 36560827

发布时间 2023-11-06

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