首页> Cell stem cell> An insulin hypersecretion phenotype precedes pancreatic β cell failure in MODY3 patient-specific cells.

An insulin hypersecretion phenotype precedes pancreatic β cell failure in MODY3 patient-specific cells.

导出 LinkOut

翻译打印收藏纠错

第一作者： Florian M,Hermann

第一单位： Novo Nordisk Foundation Center for Stem Cell Biology (DanStem), University of Copenhagen, Copenhagen, Denmark.

作者： Florian M,Hermann ^[1] ; Maya Friis,Kjærgaard ^[1] ; Chenglei,Tian ^[2] ; Ulf,Tiemann ^[1] ; Abigail,Jackson ^[1] ; Lars Rønn,Olsen ^[3] ; Maria,Kraft ^[4] ; Per-Ola,Carlsson ^[5] ; Iina M,Elfving ^[6] ; Jarno L T,Kettunen ^[7] ; Tiinamaija,Tuomi ^[7] ; Ivana,Novak ^[8] ; Henrik,Semb ^[9]

作者单位： Novo Nordisk Foundation Center for Stem Cell Biology (DanStem), University of Copenhagen, Copenhagen, Denmark. ^[1] Novo Nordisk Foundation Center for Stem Cell Biology (DanStem), University of Copenhagen, Copenhagen, Denmark; Institute of Translational Stem Cell Research, Helmholtz Diabetes Center, Helmholtz Zentrum München, München, Germany. ^[2] Department of Health Technology, Technical University of Denmark, Kongens Lyngby, Denmark. ^[3] Lund Stem Cell Center, Lund University, Lund, Sweden. ^[4] Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden; Department of Medical Sciences, Uppsala University, Uppsala, Sweden. ^[5] Folkhalsan Research Center, Helsinki, Finland. ^[6] Folkhalsan Research Center, Helsinki, Finland; Institute for Molecular Medicine Finland, University of Finland, Helsinki, Finland; Department of Endocrinology, Abdominal Center, Helsinki University Hospital, Helsinki, Finland. ^[7] Department of Biology, University of Copenhagen, Copenhagen, Denmark. ^[8] Novo Nordisk Foundation Center for Stem Cell Biology (DanStem), University of Copenhagen, Copenhagen, Denmark; Institute of Translational Stem Cell Research, Helmholtz Diabetes Center, Helmholtz Zentrum München, München, Germany. Electronic address: henrik.semb@helmholtz-muenchen.de. ^[9]

关键词 HNF1A HNF4A K(ATP) channel MODY3 calcium signaling congenital hyperinsulinemia disease modeling membrane potential pancreatic β cell patient-specific hiPSCs

医学主题词人类(Humans);小鼠(Mice);动物(Animals);胰岛素(Insulin);胰岛素分泌细胞(Insulin-Secreting Cells);糖尿病, 2型(Diabetes Mellitus, Type 2);表型(Phenotype)

DOI 10.1016/j.stem.2022.12.001

PMID 36563694

发布时间 2023-02-13

翻译满意度评价：

准确一般字义偏差语意偏离译文作用小提交