A duplex structure of SARM1 octamers stabilized by a new inhibitor.

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第一作者： Tami,Khazma

第一单位： The Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan, Israel.

作者： Tami,Khazma ^[1] ; Yarden,Golan-Vaishenker ^[2] ; Julia,Guez-Haddad ^[1] ; Atira,Grossman ^[1] ; Radhika,Sain ^[1] ; Michal,Weitman ^[3] ; Alexander,Plotnikov ^[4] ; Ran,Zalk ^[2] ; Avraham,Yaron ^[5] ; Michael,Hons ^[2] ; Yarden,Opatowsky ^[6]

作者单位： The Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan, Israel. ^[1] Department of Biomolecular Sciences, Weizmann Institute of Science, Rehovot, Israel. ^[2] Department of Chemistry, Bar-Ilan University, Ramat Gan, Israel. ^[3] The Nancy and Stephen Grand Israel National Center for Personalized Medicine, Weizmann Institute of Science, Rehovot, Israel. ^[4] Ilse Katz Institute for Nanoscale Science and Technology, Ben-Gurion University of the Negev, Beer-Sheva, Israel. ^[5] European Molecular Biology Laboratory, Grenoble, France. mhons@embl.fr. ^[6] The Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan, Israel. yarden.opatowsky@biu.ac.il. ^[7]

关键词 Cryo-EM Drug discovery NAD?+?metabolism Neurodegeneration SARM1 Structural biology

主题词轴突(Axons);蛋白质亚单位(Protein Subunits);细胞, 培养的(Cells, Cultured);Armadillo域蛋白质类(Armadillo Domain Proteins);诱变(Mutagenesis)

DOI 10.1007/s00018-022-04641-3

PMID 36564647

发布时间 2024-05-16

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