Multimodal monitoring of human cortical organoids implanted in mice reveal functional connection with visual cortex.

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作者： Madison N,Wilson ^[1] ; Martin,Thunemann ^[2] ; Xin,Liu ^[1] ; Yichen,Lu ^[1] ; Francesca,Puppo ^[3] ; Jason W,Adams ^[4] ; Jeong-Hoon,Kim ^[1] ; Mehrdad,Ramezani ^[1] ; Donald P,Pizzo ^[5] ; Srdjan,Djurovic ^[6] ; Ole A,Andreassen ^[7] ; Abed AlFatah,Mansour ^[8] ; Fred H,Gage ^[9] ; Alysson R,Muotri ^[10] ; Anna,Devor ^[11] ; Duygu,Kuzum ^[12]

作者单位： Department of Electrical and Computer Engineering, University of California San Diego, La Jolla, CA, USA. ^[1] Department of Biomedical Engineering, Boston University, Boston, MA, USA. ^[2] Department of Pediatrics, University of California San Diego, School of Medicine, La Jolla, CA, USA. ^[3] Department of Pediatrics, University of California San Diego, School of Medicine, La Jolla, CA, USA.;Department of Cellular and Molecular Medicine, University of California San Diego, School of Medicine, La Jolla, CA, USA. ^[4] Department of Pathology, University of California San Diego, La Jolla, CA, USA. ^[5] Department of Medical Genetics, Oslo University Hospital, Oslo, Norway.;NORMENT Center, Oslo, Norway.;Department of Clinical Science, University of Bergen, Bergen, Norway.;K. G. Jebsen Center for Neurodevelopmental Disorders, University of Oslo, Oslo, Norway. ^[6] NORMENT Center, Oslo, Norway.;K. G. Jebsen Center for Neurodevelopmental Disorders, University of Oslo, Oslo, Norway.;Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.;Institute of Clinical Medicine, University of Oslo, Oslo, Norway.;Oslo University Hospital, University of Oslo, Oslo, Norway. ^[7] Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, CA, USA.;Department of Medical Neurobiology, The Hebrew University of Jerusalem, Ein Kerem-Jerusalem, Israel. ^[8] Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, CA, USA. ^[9] Department of Pediatrics, University of California San Diego, School of Medicine, La Jolla, CA, USA.;Department of Cellular and Molecular Medicine, University of California San Diego, School of Medicine, La Jolla, CA, USA.;Center for Academic Research and Training in Anthropogeny, University of California San Diego, La Jolla, CA, USA.;Archealization Center, University of California San Diego, La Jolla, CA, USA.;Kavli Institute for Brain and Mind, University of California San Diego, La Jolla, CA, USA. ^[10] Department of Biomedical Engineering, Boston University, Boston, MA, USA. adevor@bu.edu.;Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Harvard Medical School, Massachusetts General Hospital, Charlestown, MA, USA. adevor@bu.edu. ^[11] Department of Electrical and Computer Engineering, University of California San Diego, La Jolla, CA, USA. dkuzum@eng.ucsd.edu. ^[12]