Non-pathogenic microbiota accelerate age-related CpG Island methylation in colonic mucosa.

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作者： Ang,Sun ^[1] ; Pyounghwa,Park ^[1] ; Lauren,Cole ^[2] ; Himani,Vaidya ^[1] ; Shinji,Maegawa ^[1] ; Kelsey,Keith ^[2] ; Gennaro,Calendo ^[1] ; Jozef,Madzo ^[3] ; Jaroslav,Jelinek ^[1] ; Christian,Jobin ^[2] ; Jean-Pierre J,Issa ^[2]

作者单位： Fels Cancer Institute for Personalized Medicine, Temple University School of Medicine, Philadelphia, PA, United States. ^[1] Coriell Institute for Medical Research, Camden, NJ, United States. ^[2] Research Department of Pediatrics, University of Texas, MD Anderson Cancer Center Department of Pediatrics, University of Texas, MD Anderson Cancer Center Houston, TX, USA. ^[3] Department of Medicine, Division of Gastroenterology, Hepatology, and Nutrition, University of Florida College of Medicine, Gainesville, Florida, USA. ^[4]

关键词 Ageing DNA methylation Germ-free Inflammation Microbiota

主题词动物(Animals);小鼠(Mice);CpG岛(CpG Islands);DNA甲基化(DNA Methylation);结直肠肿瘤(Colorectal Neoplasms);结肠肿瘤(Colonic Neoplasms);黏膜(Mucous Membrane)

DOI 10.1080/15592294.2022.2160568

PMID 36572998

发布时间 2024-03-27

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